Measuring heritable contributions to Alzheimer's disease: polygenic risk score analysis with twins.
APOE
Alzheimer’s disease
heritability
polygenic risk scores (PRSs)
twins
Journal
Brain communications
ISSN: 2632-1297
Titre abrégé: Brain Commun
Pays: England
ID NLM: 101755125
Informations de publication
Date de publication:
2022
2022
Historique:
received:
20
05
2021
revised:
17
09
2021
accepted:
18
10
2021
entrez:
16
2
2022
pubmed:
17
2
2022
medline:
17
2
2022
Statut:
epublish
Résumé
The heritability of Alzheimer's disease estimated from twin studies is greater than the heritability derived from genome-based studies, for reasons that remain unclear. We apply both approaches to the same twin sample, considering both Alzheimer's disease polygenic risk scores and heritability from twin models, to provide insight into the role of measured genetic variants and to quantify uncaptured genetic risk. A population-based heritability and polygenic association study of Alzheimer's disease was conducted between 1986 and 2016 and is the first study to incorporate polygenic risk scores into biometrical twin models of Alzheimer's disease. The sample included 1586 twins drawn from the Swedish Twin Registry which were nested within 1137 twin pairs (449 complete pairs and 688 incomplete pairs) with clinically based diagnoses and registry follow-up (
Identifiants
pubmed: 35169705
doi: 10.1093/braincomms/fcab308
pii: fcab308
pmc: PMC8833403
doi:
Types de publication
Journal Article
Langues
eng
Pagination
fcab308Subventions
Organisme : Medical Research Council
ID : MR/K01417X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/T033371/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1001253
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L501542/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L010305/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/T04604X/1
Pays : United Kingdom
Organisme : Parkinson's UK
ID : G-1307
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0901254
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0801418
Pays : United Kingdom
Organisme : Parkinson's UK
ID : G-0907
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P005748/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/J004758/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L023784/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0701075
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : RF1 AG058068
Pays : United States
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of the Guarantors of Brain.
Références
Nature. 2012 Nov 1;491(7422):56-65
pubmed: 23128226
JAMA Netw Open. 2019 Mar 1;2(3):e191350
pubmed: 30924900
Behav Genet. 2009 Mar;39(2):220-9
pubmed: 19083089
Nature. 2012 Aug 2;488(7409):96-9
pubmed: 22801501
Arch Neurol. 2012 May;69(5):636-43
pubmed: 22232206
Nat Commun. 2020 Sep 23;11(1):4799
pubmed: 32968074
Science. 1997 Jun 6;276(5318):1560-3
pubmed: 9171059
Age (Dordr). 2013 Apr;35(2):487-500
pubmed: 22234866
Behav Genet. 2021 May;51(3):237-249
pubmed: 33523349
Nat Genet. 2019 Mar;51(3):414-430
pubmed: 30820047
J Gerontol B Psychol Sci Soc Sci. 2002 May;57(3):S168-76
pubmed: 11983743
Twin Res Hum Genet. 2013 Feb;16(1):317-29
pubmed: 23137839
Nat Rev Genet. 2013 Jul;14(7):507-15
pubmed: 23774735
Elife. 2019 Oct 24;8:
pubmed: 31647416
Genes (Basel). 2019 Mar 15;10(3):
pubmed: 30884759
J Alzheimers Dis. 2020;76(2):539-551
pubmed: 32538833
Neurobiol Aging. 2017 Jan;49:214.e7-214.e11
pubmed: 27595457
Nat Genet. 2013 Dec;45(12):1452-8
pubmed: 24162737
Nat Genet. 2015 Oct;47(10):1114-20
pubmed: 26323059
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
Twin Res Hum Genet. 2005 Jun;8(3):214-23
pubmed: 15989749
Behav Genet. 2019 Jan;49(1):99-111
pubmed: 30569348
Alzheimers Res Ther. 2021 Mar 4;13(1):55
pubmed: 33663605
Neurobiol Aging. 2016 May;41:200.e13-200.e20
pubmed: 27036079
Ann Neurol. 2017 Aug;82(2):311-314
pubmed: 28727176
Behav Genet. 2017 Mar;47(2):255-261
pubmed: 27866285
J Mol Neurosci. 2016 Nov;60(3):316-324
pubmed: 27498201
Gigascience. 2015 Feb 25;4:7
pubmed: 25722852
Psychometrika. 2016 Jun;81(2):535-49
pubmed: 25622929
Nat Genet. 2017 Sep;49(9):1373-1384
pubmed: 28714976
Neurosci Biobehav Rev. 2019 Aug;103:73-80
pubmed: 31207254
Ann Neurol. 2015 Sep;78(3):487-98
pubmed: 26101835
Behav Genet. 2016 Jan;46(1):20-30
pubmed: 26318288
Nat Neurosci. 2020 Mar;23(3):311-322
pubmed: 32112059
Nat Genet. 2016 Jan;48(1):30-5
pubmed: 26569126
Behav Genet. 2016 Jan;46(1):4-19
pubmed: 26538244
Elife. 2019 Oct 24;8:
pubmed: 31647408
Neurobiol Aging. 2005 Apr;26(4):439-47
pubmed: 15653172
J Alzheimers Dis. 2019;71(3):741-750
pubmed: 31450492
J Alzheimers Dis. 2018;61(4):1301-1310
pubmed: 29376854
Neurobiol Aging. 2013 Jun;34(6):1710.e11-8
pubmed: 23318115
Nat Genet. 2019 Sep;51(9):1423-1424
pubmed: 31417202
J Alzheimers Dis. 2018;64(4):1077-1083
pubmed: 30010124
Nat Commun. 2021 Jul 23;12(1):4506
pubmed: 34301930
Lancet Neurol. 2016 Jul;15(8):857-868
pubmed: 27302364
J Prev Alzheimers Dis. 2019;6(1):16-19
pubmed: 30569081
Brain. 2015 Dec;138(Pt 12):3673-84
pubmed: 26490334
Am J Epidemiol. 2011 Jun 15;173(12):1357-64
pubmed: 21498624
Arch Gen Psychiatry. 2006 Feb;63(2):168-74
pubmed: 16461860