Regulation of lysosomal trafficking of progranulin by sortilin and prosaposin.
frontotemporal lobar degeneration
lysosome
progranulin
prosaposin
sortilin
Journal
Brain communications
ISSN: 2632-1297
Titre abrégé: Brain Commun
Pays: England
ID NLM: 101755125
Informations de publication
Date de publication:
2022
2022
Historique:
received:
20
08
2021
revised:
19
10
2021
accepted:
13
12
2021
entrez:
16
2
2022
pubmed:
17
2
2022
medline:
17
2
2022
Statut:
epublish
Résumé
Haploinsufficiency of the progranulin protein is a leading cause of frontotemporal lobar degeneration. Accumulating evidence support a crucial role of progranulin in the lysosome. Progranulin comprises 7.5 granulin repeats and is known to traffic to lysosomes via direct interactions with prosaposin or sortilin. Within the lysosome, progranulin gets processed into granulin peptides. Here, we report that sortilin and prosaposin independently regulate lysosomal trafficking of progranulin
Identifiants
pubmed: 35169707
doi: 10.1093/braincomms/fcab310
pii: fcab310
pmc: PMC8833632
doi:
Types de publication
Journal Article
Langues
eng
Pagination
fcab310Subventions
Organisme : NINDS NIH HHS
ID : R01 NS088448
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS095954
Pays : United States
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of the Guarantors of Brain.
Références
Am J Pathol. 2010 Jul;177(1):311-24
pubmed: 20522652
J Endocrinol. 1998 Aug;158(2):145-51
pubmed: 9771457
J Mol Biol. 2019 Mar 1;431(5):1038-1047
pubmed: 30690031
J Pathol. 2009 Oct;219(2):173-81
pubmed: 19557827
Neurobiol Aging. 2011 Dec;32(12):2326.e5-16
pubmed: 21820214
Nat Rev Neurosci. 2017 Jun;18(6):325-333
pubmed: 28435163
Lancet Neurol. 2005 Nov;4(11):771-80
pubmed: 16239184
Cell. 2002 Dec 13;111(6):867-78
pubmed: 12526812
Nat Commun. 2017 May 25;8:15277
pubmed: 28541286
Am J Hum Genet. 2012 Jun 8;90(6):1102-7
pubmed: 22608501
Hum Mol Genet. 2020 Mar 27;29(5):716-726
pubmed: 31600775
Am J Physiol Cell Physiol. 2011 Apr;300(4):C723-42
pubmed: 21209361
J Neurochem. 2010 Nov;115(3):735-47
pubmed: 20731760
Nature. 2006 Aug 24;442(7105):920-4
pubmed: 16862115
J Neuroinflammation. 2007 Feb 11;4:7
pubmed: 17291356
Brain Res. 2009 Jan 16;1249:202-11
pubmed: 19046946
Bioorg Med Chem Lett. 2020 Sep 1;30(17):127403
pubmed: 32738972
Neurobiol Aging. 2016 May;41:200.e1-200.e5
pubmed: 27021778
Hum Mol Genet. 1996 Jun;5(6):711-25
pubmed: 8776585
eNeuro. 2017 Aug 18;4(4):
pubmed: 28828399
Science. 2009 Jul 24;325(5939):473-7
pubmed: 19556463
Mol Neurodegener. 2017 Jul 25;12(1):55
pubmed: 28743268
Am J Hum Genet. 2010 Dec 10;87(6):890-7
pubmed: 21087763
Hum Mol Genet. 2014 Mar 15;23(6):1467-78
pubmed: 24163244
Acta Neuropathol. 2014;127(6):845-60
pubmed: 24619111
Sci Transl Med. 2017 Apr 12;9(385):
pubmed: 28404863
Nature. 2004 Feb 26;427(6977):843-8
pubmed: 14985763
J Exp Med. 2010 Jan 18;207(1):117-28
pubmed: 20026663
Acta Neuropathol. 2017 Jul;134(1):151-153
pubmed: 28493053
Hum Mol Genet. 2017 Dec 15;26(24):4861-4872
pubmed: 29036611
Mol Neurodegener. 2017 Aug 23;12(1):62
pubmed: 28835281
Mol Neurodegener. 2022 Feb 4;17(1):15
pubmed: 35120524
Am J Alzheimers Dis Other Demen. 2009 Dec-2010 Jan;24(6):456-60
pubmed: 19776335
PLoS One. 2010 Oct 13;5(10):e13368
pubmed: 20967127
PLoS One. 2019 Jul 10;14(7):e0212382
pubmed: 31291241
Hum Mol Genet. 2006 Oct 15;15(20):2988-3001
pubmed: 16950801
J Cell Biol. 2008 Apr 7;181(1):37-41
pubmed: 18378771
Acta Neuropathol. 2010 Jan;119(1):111-22
pubmed: 19649643
Nucleic Acids Res. 2011 Nov 1;39(20):8677-88
pubmed: 21785136
Front Neurosci. 2020 Dec 15;14:586107
pubmed: 33384578
Nature. 2006 Aug 24;442(7105):916-9
pubmed: 16862116
Acta Neuropathol Commun. 2019 Dec 23;7(1):218
pubmed: 31870439
Hum Mol Genet. 2017 Aug 1;26(15):2850-2863
pubmed: 28453791
J Cell Biol. 2015 Sep 14;210(6):991-1002
pubmed: 26370502
Neuron. 2010 Nov 18;68(4):654-67
pubmed: 21092856
Neurology. 2002 Jun 11;58(11):1615-21
pubmed: 12058088
Acta Neuropathol. 2018 Jul;136(1):1-17
pubmed: 29744576
Alzheimers Res Ther. 2012 Jan 23;4(1):4
pubmed: 22277331
BMC Neurosci. 2009 Oct 27;10:130
pubmed: 19860916
FASEB J. 1991 Mar 1;5(3):301-8
pubmed: 2001789