Blood amyloid and tau biomarkers as predictors of cerebrospinal fluid profiles.
Biomarkers
Blood
CSF
Clinical management
Lumbar puncture
Journal
Journal of neural transmission (Vienna, Austria : 1996)
ISSN: 1435-1463
Titre abrégé: J Neural Transm (Vienna)
Pays: Austria
ID NLM: 9702341
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
30
12
2021
accepted:
05
02
2022
pubmed:
17
2
2022
medline:
17
3
2022
entrez:
16
2
2022
Statut:
ppublish
Résumé
Blood biomarkers represent a major advance for improving the management, diagnosis, and monitoring of Alzheimer's disease (AD). However, their context of use in relation to routine cerebrospinal fluid (CSF) analysis for the quantification of amyloid peptides and tau proteins remains to be determined. We studied in two independent cohorts, the performance of blood biomarkers in detecting "nonpathological" (A-/T-/N-), amyloid (A+) or neurodegenerative (T+ /N+) CSF profiles. Plasma Aβ The use of blood biomarkers to identify patients who may benefit from secondary CSF testing represents an attractive stratification strategy in the clinical management of patients visiting memory clinics. This could reduce the need for lumbar puncture and foreshadow the use of blood testing on larger populations.
Identifiants
pubmed: 35169889
doi: 10.1007/s00702-022-02474-9
pii: 10.1007/s00702-022-02474-9
pmc: PMC8866346
doi:
Substances chimiques
Amyloid beta-Peptides
0
Biomarkers
0
MAPT protein, human
0
Peptide Fragments
0
tau Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
231-237Informations de copyright
© 2022. The Author(s).
Références
Proteomics Clin Appl. 2008 Oct;2(10-11):1548-56
pubmed: 21136802
J Alzheimers Dis. 2020;75(3):937-947
pubmed: 32390628
Alzheimers Dement (N Y). 2019 Oct 14;5:597-609
pubmed: 31650016
Lancet Neurol. 2014 Jun;13(6):614-29
pubmed: 24849862
Nat Med. 2021 Jun;27(6):1034-1042
pubmed: 34031605
J Neurol Neurosurg Psychiatry. 2018 May;89(5):467-475
pubmed: 29321140
Alzheimers Res Ther. 2021 Dec 4;13(1):198
pubmed: 34863295
Clin Chim Acta. 2019 Aug;495:451-456
pubmed: 31051163
Alzheimers Res Ther. 2020 Oct 2;12(1):123
pubmed: 33008460
Nature. 2018 Feb 8;554(7691):249-254
pubmed: 29420472
Alzheimers Dement. 2014 Oct;10(5 Suppl):S390-S394.e2
pubmed: 24269268
Alzheimers Dement. 2018 Apr;14(4):535-562
pubmed: 29653606
JAMA Neurol. 2021 Nov 1;78(11):1375-1382
pubmed: 34542571
Alzheimers Res Ther. 2018 Jul 28;10(1):71
pubmed: 30055655
Alzheimers Dement. 2018 Sep;14(9):1159-1170
pubmed: 30049650
Front Aging Neurosci. 2018 May 28;10:138
pubmed: 29892221
J Alzheimers Dis. 2011;26(3):553-63
pubmed: 21709372
Alzheimers Dement. 2021 Aug;17(8):1353-1364
pubmed: 33580742
Alzheimers Res Ther. 2020 Mar 17;12(1):26
pubmed: 32183883
J Neurol Neurosurg Psychiatry. 2021 Nov;92(11):1206-1214
pubmed: 34103344
BMC Bioinformatics. 2006 Oct 10;7:442
pubmed: 17032455
Alzheimers Dement. 2011 May;7(3):263-9
pubmed: 21514250
Biometrics. 1988 Sep;44(3):837-45
pubmed: 3203132
J Neurol. 2012 Nov;259(11):2429-33
pubmed: 22576334
Neurology. 2016 Aug 2;87(5):539-47
pubmed: 27371494