The Role of (Pro)Renin Receptor in the Metabolic Syndrome.
(Pro)renin receptor
Wnt/β-catenin signaling
blood pressure
hypertension
lipolysis
metabolic syndrome
metabolism
single transmembrane protein receptor
Journal
Current hypertension reviews
ISSN: 1875-6506
Titre abrégé: Curr Hypertens Rev
Pays: United Arab Emirates
ID NLM: 101239891
Informations de publication
Date de publication:
2022
2022
Historique:
received:
25
08
2021
revised:
29
12
2021
accepted:
06
01
2022
pubmed:
17
2
2022
medline:
15
12
2022
entrez:
16
2
2022
Statut:
ppublish
Résumé
The prorenin receptor (PRR) is a complex multi-functional single transmembrane protein receptor that is ubiquitously expressed in organs and tissues throughout the body. PRR is involved in different cellular mechanisms that comprise the generation of Angiotensin II, the activation of Wnt/β-catenin signaling, the stimulation of ERK 1/2 pathway, and the proper functioning of the vacuolar H+-ATPase. Evidence supports the role of PRR and its soluble form, sPRR, in the classical features of the metabolic syndrome, including obesity, hypertension, diabetes, and disruption of lipid homeostasis. This review summarizes our current knowledge and highlights new advances in the pathophysiological function of PRR and sPRR in adipogenesis, adipocyte differentiation, lipolysis, glucose and insulin resistance, lipid homeostasis, energy metabolism, and blood pressure regulation.
Identifiants
pubmed: 35170416
pii: CHYR-EPUB-120932
doi: 10.2174/1573402118666220216104816
doi:
Substances chimiques
ATP6AP2 protein, human
0
Lipids
0
Prorenin Receptor
0
Receptors, Cell Surface
0
Renin
EC 3.4.23.15
Vacuolar Proton-Translocating ATPases
EC 3.6.1.-
Types de publication
Review
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
117-124Subventions
Organisme : NIH HHS
ID : R01-HL-142969
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM127211
Pays : United States
Organisme : University of Kentucky, Center for Clinical and Translational Sciences
ID : UL1TR001998
Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.