Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains.


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
16 02 2022
Historique:
received: 28 06 2021
accepted: 28 01 2022
entrez: 17 2 2022
pubmed: 18 2 2022
medline: 3 3 2022
Statut: epublish

Résumé

Mechanisms underlying variability in transmission of Mycobacterium tuberculosis strains remain undefined. By characterizing high and low transmission strains of M.tuberculosis in mice, we show here that high transmission M.tuberculosis strain induce rapid IL-1R-dependent alveolar macrophage migration from the alveolar space into the interstitium and that this action is key to subsequent temporal events of early dissemination of bacteria to the lymph nodes, Th1 priming, granulomatous response and bacterial control. In contrast, IL-1R-dependent alveolar macrophage migration and early dissemination of bacteria to lymph nodes is significantly impeded in infection with low transmission M.tuberculosis strain; these events promote the development of Th17 immunity, fostering neutrophilic inflammation and increased bacterial replication. Our results suggest that by inducing granulomas with the potential to develop into cavitary lesions that aids bacterial escape into the airways, high transmission M.tuberculosis strain is poised for greater transmissibility. These findings implicate bacterial heterogeneity as an important modifier of TB disease manifestations and transmission.

Identifiants

pubmed: 35173157
doi: 10.1038/s41467-022-28506-2
pii: 10.1038/s41467-022-28506-2
pmc: PMC8850437
doi:

Substances chimiques

IL1R1 protein, mouse 0
Receptors, Interleukin-1 Type I 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

884

Subventions

Organisme : NIAID NIH HHS
ID : T32 AI125185
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI065663
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI111276
Pays : United States

Informations de copyright

© 2022. The Author(s).

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Auteurs

Arianne Lovey (A)

Center for Emerging Pathogens, Department of Medicine, Rutgers-New Jersey Medical School, Newark, NJ, USA.

Sheetal Verma (S)

Center for Emerging Pathogens, Department of Medicine, Rutgers-New Jersey Medical School, Newark, NJ, USA.

Vaishnavi Kaipilyawar (V)

Center for Emerging Pathogens, Department of Medicine, Rutgers-New Jersey Medical School, Newark, NJ, USA.

Rodrigo Ribeiro-Rodrigues (R)

Núcleo de Doenças Infecciosas, NDI/Universidade Federal do Espirito Santo-UFES, Vitoria, Brazil.

Seema Husain (S)

The Genomics Center, Rutgers-New Jersey Medical School, Newark, NJ, USA.

Moises Palaci (M)

Núcleo de Doenças Infecciosas, NDI/Universidade Federal do Espirito Santo-UFES, Vitoria, Brazil.

Reynaldo Dietze (R)

Núcleo de Doenças Infecciosas, NDI/Universidade Federal do Espirito Santo-UFES, Vitoria, Brazil.
Global Health & Tropical Medicine-Instituto de Higiene e Medicina Tropical-Universidade Nova de Lisboa, Lisbon, Portugal.

Shuyi Ma (S)

Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
Division of Infectious Diseases, Department of Pediatrics, University of Washington, Seattle, WA, USA.
Pathobiology Program, Department of Global Health, University of Washington, Seattle, WA, USA.
Department of Chemical Engineering, University of Washington, Seattle, WA, USA.

Robert D Morrison (RD)

Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.

David R Sherman (DR)

Department of Microbiology, University of Washington, Seattle, WA, 98109-8070, USA.

Jerrold J Ellner (JJ)

Center for Emerging Pathogens, Department of Medicine, Rutgers-New Jersey Medical School, Newark, NJ, USA.

Padmini Salgame (P)

Center for Emerging Pathogens, Department of Medicine, Rutgers-New Jersey Medical School, Newark, NJ, USA. padmini.salgame@rutgers.edu.

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