Pigment Epithelium Derived Factor Is Involved in the Late Phase of Osteosarcoma Metastasis by Increasing Extravasation and Cell-Cell Adhesion.
extravasation
mesenchymal to epithelial transition (MET)
metastasis
osteosarcoma
pigment epithelium derived factor (PEDF)
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2022
2022
Historique:
received:
19
11
2021
accepted:
07
01
2022
entrez:
17
2
2022
pubmed:
18
2
2022
medline:
18
2
2022
Statut:
epublish
Résumé
Organ tropism of metastatic cells is not well understood. To determine the key factors involved in the selection of a specific organ upon metastasis, we established metastatic cell lines and analyzed their homing to specific tissues. Toward this, 143B osteosarcoma cells were injected intracardially until the kidney-metastasizing sub-cell line Bkid was established, which significantly differed from the parental 143B cells. The candidate genes responsible for kidney metastasis were validated, and SerpinF1/Pigment epithelium derived factor (PEDF) was identified as the primary target. Bkid cells with PEDF knockdown injected intracardially did not metastasize to the kidneys. In contrast, PEDF overexpressing 143B cells injected into femur metastasized to the lungs and kidneys. PEDF triggered mesenchymal-to-epithelial transition (MET)
Identifiants
pubmed: 35174090
doi: 10.3389/fonc.2022.818182
pmc: PMC8842676
doi:
Types de publication
Journal Article
Langues
eng
Pagination
818182Informations de copyright
Copyright © 2022 Kuriyama, Tanaka, Takagane, Itoh and Tanaka.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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