Efficacy and Safety of 8- or 12 Weeks of Glecaprevir/Pibrentasvir in Patients with Evidence of Portal Hypertension.

Glecaprevir Hepatitis C Pibrentasvir Portal Hypertension Sustained Virologic Response

Journal

Infectious diseases and therapy
ISSN: 2193-8229
Titre abrégé: Infect Dis Ther
Pays: New Zealand
ID NLM: 101634499

Informations de publication

Date de publication:
Apr 2022
Historique:
received: 01 12 2021
accepted: 28 01 2022
pubmed: 18 2 2022
medline: 18 2 2022
entrez: 17 2 2022
Statut: ppublish

Résumé

High efficacy and safety of 8-week glecaprevir/pibrentasvir (G/P) therapy was seen in hepatitis C (HCV)-infected, treatment-naïve (TN), compensated cirrhosis (CC) patients in EXPEDITION-8. To provide further understanding of the efficacy of G/P treatment in HCV-infected TN patients with CC and clinical evidence of portal hypertension (PHT), this analysis focused on differences in sustained virologic response at post-treatment week 12 (SVR12) between 8-week and 12-week G/P treatment groups in patients with PHT, and on differences in safety outcomes between PHT and non-PHT groups. Data were derived from an ad hoc subgroup analysis of the EXPEDITION-8 study for patients receiving 8 weeks of G/P therapy, and pooled patient-level data from nine clinical studies for patients receiving 12 weeks of therapy. Evidence of PHT included at least one of the following at baseline: FibroScan ≥ 20 kPa, platelets < 100 × 10 PHT was identified in 60.6% (208/343) and 57.1% (224/392) of the 8- and 12-week groups, respectively. For those with PHT, SVR12 was 97.6% (203/208) and 98.7% (221/224) with 8- and 12-week treatment, respectively (intention-to-treat population). For those without PHT, 97.8% (132/135) in the 8-week group and 97.6% (164/168) in the 12-week group achieved SVR12. Eight patients with PHT, and seven without, did not achieve SVR12. Similar rates of AEs were observed in the PHT and non-PHT groups. Three cases of hepatic decompensation in the PHT group, unrelated to G/P according to the investigators, were reported. G/P treatment for 8 or 12 weeks was equally efficacious in HCV patients with features of PHT. Safety outcomes were similar between PHT and non-PHT groups, with G/P treatment well tolerated across groups. NCTS: NCT03089944, NCT02642432, NCT02738138, NCT02243293, NCT02651194, NCT03235349, NCT02707952, NCT02966795, NCT03069365, NCT03219216.

Identifiants

pubmed: 35174470
doi: 10.1007/s40121-022-00599-8
pii: 10.1007/s40121-022-00599-8
pmc: PMC8960502
doi:

Banques de données

ClinicalTrials.gov
['NCT03069365', 'NCT02966795', 'NCT02707952', 'NCT03219216']

Types de publication

Journal Article

Langues

eng

Pagination

913-924

Informations de copyright

© 2022. The Author(s).

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Auteurs

Robert S Brown (RS)

Center for Liver Disease and Transplantation, Weill Cornell Medical College, 1305 York Avenue, New York, NY, 10021, USA. rsb2005@med.cornell.edu.

Michelle A Collins (MA)

AbbVie Inc., North Chicago, IL, USA.

Simone I Strasser (SI)

AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Sydney, NSW, Australia.

Amanda Emmett (A)

AbbVie Inc., North Chicago, IL, USA.

Andrew S Topp (AS)

AbbVie Inc., North Chicago, IL, USA.

Margaret Burroughs (M)

AbbVie Inc., North Chicago, IL, USA.

Rosa Ferreira (R)

AbbVie Inc., North Chicago, IL, USA.

Jordan J Feld (JJ)

Toronto Centre for Liver Disease, University Health Network, University of Toronto, Toronto, ON, Canada.

Classifications MeSH