Synaptic density and cognitive performance in Alzheimer's disease: A PET imaging study with [
Alzheimer's disease
[11C]UCB-J
cognition
synaptic density
synaptic vesicle glycoprotein 2A
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
revised:
23
11
2021
received:
08
09
2021
accepted:
12
12
2021
pubmed:
18
2
2022
medline:
3
1
2023
entrez:
17
2
2022
Statut:
ppublish
Résumé
For 30 years synapse loss has been referred to as the major pathological correlate of cognitive impairment in Alzheimer's disease (AD). However, this statement is based on remarkably few patients studied by autopsy or biopsy. With the recent advent of synaptic vesicle glycoprotein 2A (SV2A) positron emission tomography (PET) imaging, we have begun to evaluate the consequences of synaptic alterations in vivo. We examined the relationship between synaptic density measured by [ Global synaptic density showed a significant positive association with global cognition and performance on five individual cognitive domains in participants with early AD. Synaptic density was a stronger predictor of cognitive performance than gray matter volume. These results confirm neuropathologic studies demonstrating a significant association between synaptic density and cognitive performance, and suggest that this correlation extends to the early stages of AD.
Identifiants
pubmed: 35174954
doi: 10.1002/alz.12582
pmc: PMC9381645
mid: NIHMS1766176
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2527-2536Subventions
Organisme : National Center for Advancing Translational Science
ID : UL1TR000142
Organisme : NIA NIH HHS
ID : K23 AG057794
Pays : United States
Organisme : The National Institute on Aging
ID : P50AG047270
Organisme : The National Institute of Mental Health
ID : T32MH019961
Organisme : The National Institute on Aging
ID : R01AG052560
Organisme : The National Institute on Aging
ID : RF1AG057553
Organisme : The National Institute on Aging
ID : K23AG057784
Organisme : The National Institute on Aging
ID : P30AG021342
Organisme : The National Institute on Aging
ID : P30AG066508
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066508
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG062276
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG052560
Pays : United States
Organisme : The National Institute on Aging
ID : R01AG062276
Informations de copyright
© 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
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