Assessment of Surface Glycan Diversity on Extracellular Vesicles by Lectin Microarray and Glycoengineering Strategies for Drug Delivery Applications.
diversity
extracellular vesicles
glycans
glycoengineering
lectin microarrays
Journal
Small methods
ISSN: 2366-9608
Titre abrégé: Small Methods
Pays: Germany
ID NLM: 101724536
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
revised:
08
11
2021
received:
09
07
2021
entrez:
17
2
2022
pubmed:
18
2
2022
medline:
26
3
2022
Statut:
ppublish
Résumé
Extracellular vesicles (EVs) are released by all types of mammalian cells for cell-cell communication. In this study, surface glycans on EVs are compared in terms of their cell type, size, and isolation method to examine whether EV glycan profiles by lectin microarray can be used to define EV subpopulations. Moreover, EVs are glycoengineered with four distinctive surface glycan patterns and evaluated their cellular uptake efficiencies for potential drug delivery applications. Both similarities and differences in glycan patterns are identified on EVs obtained under each experimental condition. EV size- and isolation method-dependent lectin-binding patterns are observed. Moreover, cellular uptake behaviors of EVs are affected by EV glycan profiles and acceptor cells. The in vivo biodistribution of EVs is also dependent on their glycan profile. These results suggest that EV surface glycans are a potential novel indicator of EV heterogeneity, and glycoengineering is a useful approach to regulate cell-EV interactions for biomedical applications.
Identifiants
pubmed: 35174988
doi: 10.1002/smtd.202100785
doi:
Substances chimiques
Lectins
0
Polysaccharides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2100785Subventions
Organisme : Tokyo Medical and Dental University
Organisme : Japan Society for the Promotion of Science
ID : 17K13029
Organisme : CREST, Japan Science and Technology Agency
ID : JPMJCR17H2
Informations de copyright
© 2021 Wiley-VCH GmbH.
Références
E. Armingol, A. Officer, O. Harismendy, N. E. Lewis, Nat. Rev. Genet. 2021, 22, 71.
R. Kalluri, V. S. LeBleu, Science 2020, 367, 6478.
M. Mathieu, L. Martin-Jaular, G. Lavieu, C. Théry, Nat. Cell Biol. 2019, 21, 9.
H. Zhang, D. Freitas, H. S. Kim, K. Fabijanic, Z. Li, H. Chen, M. T. Mark, H. Molina, A. B. Martin, L. Bojmar, Nat. Cell Biol. 2018, 20, 332.
G. Huang, G. Lin, Y. Zhu, W. Duan, D. Jin, Lab Chip 2020, 20, 2423.
J. Lötvall, A. F. Hill, F. Hochberg, E. I. Buzás, D. Di Vizio, C. Gardiner, Y. S. Gho, I. V. Kurochkin, S. Mathivanan, P. Quesenberry, S. Sahoo, H. Tahara, M. H. Wauben, K. W. Witwer, C. Théry, J. Extracell. Vesicles 2014, 3, 26913.
C. Théry, K. W. Witwer, E. Aikawa, M. J. Alcaraz, J. D. Anderson, R. Andriantsitohaina, A. Antoniou, T. Arab, F. Archer, G. K. Atkin-Smith, D. C. Ayre, J. M. Bach, D. Bachurski, H. Baharvand, L. Balaj, S. Baldacchino, N. N. Bauer, A. A. Baxter, M. Bebawy, C. Beckham, A. Bedina Zavec, A. Benmoussa, A. C. Berardi, P. Bergese, E. Bielska, C. Blenkiron, S. Bobis-Wozowicz, E. Boilard, W. Boireau, A. Bongiovanni, et al., J. Extracell. Vesicles 2018, 7, 1535750.
E. Willms, H. J. Johansson, I. Mäger, Y. Lee, K. E. Blomberg, M. Sadik, A. Alaarg, C. I. Smith, J. Lehtiö, S. El Andaloussi, M. J. Wood, P. Vader, Sci. Rep. 2016, 6, 22519.
L. Xu, R. C. Gimple, W. B. Lau, B. Lau, F. Fei, Q. Shen, X. Liao, Y. Li, W. Wang, Y. He, M. Feng, H. Bu, W. Wang, S. Zhou, Mass Spectrom. Rev. 2020, 39, 745.
K. O'Brien, K. Breyne, S. Ughetto, L. C. Laurent, X. O. Breakefield, Nat. Rev. Mol. Cell Biol. 2020, 21, 585.
E. Willms, C. Cabañas, I. Mäger, M. J. Wood, P. Vader, Front. Immunol. 2018, 9, 738.
S. Gurunathan, M.-H. Kang, M. Jeyaraj, M. Qasim, J.-H. Kim, Cells 2019, 8, 307.
K. Sidhom, P. O. Obi, A. Saleem, Int. J. Mol. Sci. 2020, 21, 6466.
S. Gandham, X. Su, J. Wood, A. L. Nocera, S. C. Alli, L. Milane, A. Zimmerman, M. Amiji, A. R. Ivanov, Trends Biotechnol. 2020, 38, 1066.
S. Tiwari, V. Kumar, S. Randhawa, S. K. Verma, Am. J. Reprod. Immunol. 2021, 85, e13367.
D. K. Jeppesen, A. M. Fenix, J. L. Franklin, J. N. Higginbotham, Q. Zhang, L. J. Zimmerman, D. C. Liebler, J. Ping, Q. Liu, R. Evans, W. H. Fissell, J. G. Patton, L. H. Rome, D. T. Burnette, R. J. Coffey, Cell 2019, 177, 428.
W. Nakai, T. Yoshida, D. Diez, Y. Miyatake, T. Nishibu, N. Imawaka, K. Naruse, Y. Sadamura, R. Hanayama, Sci. Rep. 2016, 6, 33935.
S. Matsumura, T. Minamisawa, K. Suga, H. Kishita, T. Akagi, T. Ichiki, Y. Ichikawa, K. Shiba, J. Extracell. Vesicles 2019, 8, 1579541.
J. Kowal, G. Arras, M. Colombo, M. Jouve, J. P. Morath, B. Primdal-Bengtson, F. Dingli, D. Loew, M. Tkach, C. Théry, Proc. Natl. Acad. Sci. USA 2016, 113, E968.
C. Reily, T. J. Stewart, M. B. Renfrow, J. Novak, Nat. Rev. Nephrol. 2019, 15, 346.
A. Varki, Glycobiology 2017, 27, 3.
C. Williams, F. Royo, O. Aizpurua-Olaizola, R. Pazos, G.-J. Boons, N.-C. Reichardt, J. M. Falcon-Perez, J. Extracell. Vesicles 2018, 7, 1442985.
Á. M. Martins, C. C. Ramos, D. Freitas, C. A. Reis, Cells 2021, 10, 109.
S. A. Dusoswa, S. K. Horrevorts, M. Ambrosini, H. Kalay, N. J. Paauw, R. Nieuwland, M. D. Pegtel, T. Würdinger, Y. Van Kooyk, J. J. Garcia-Vallejo, J. Extracell. Vesicles 2019, 8, 1648995.
M. E. Kuipers, E. N. Nolte-'t Hoen, A. J. van der Ham, A. Ozir-Fazalalikhan, D. L. Nguyen, C. M. de Korne, R. I. Koning, J. J. Tomes, K. F. Hoffmann, H. H. Smits, J. Extracell. Vesicles 2020, 9, 1753420.
C. Williams, R. Pazos, F. Royo, E. González, M. Roura-Ferrer, A. Martinez, J. Gamiz, N.-C. Reichardt, J. M. Falcón-Pérez, Sci. Rep. 2019, 9, 11920.
N. Nishida-Aoki, N. Tominaga, N. Kosaka, T. Ochiya, J. Extracell. Vesicles 2020, 9, 1713527.
J. l. Costa, M. Gatermann, M. Nimtz, S. Kandzia, M. Glatzel, H. S. Conradt, Anal. Chem. 2018, 90, 7871.
M. Surman, D. Hoja-Łukowicz, S. Szwed, A. Drożdż, E. Stępień, M. Przybyło, Life Sci. 2018, 207, 395.
J. Gomes, P. Gomes-Alves, S. B. Carvalho, C. Peixoto, P. M. Alves, P. Altevogt, J. Costa, Biomolecules 2015, 5, 1741.
J. Q. Gerlach, A. Krüger, S. Gallogly, S. A. Hanley, M. C. Hogan, C. J. Ward, L. Joshi, M. D. Griffin, PLoS One 2013, 8, e74801.
A. Shimoda, Y. Tahara, S. Sawada, Y. Sasaki, K. Akiyoshi, Biochem. Biophys. Res. Commun. 2017, 491, 701.
A. Shimoda, S. Sawada, Y. Sasaki, K. Akiyoshi, Sci. Rep. 2019, 9, 11497.
A. Matsuda, A. Kuno, M. Yoshida, T. Wagatsuma, T. Sato, M. Miyagishi, J. Zhao, M. Suematsu, Y. Kabe, H. Narimatsu, J. Proteome Res. 2020, 19, 2516.
T. Ishida, T. Hashimoto, K. Masaki, H. Funabashi, R. Hirota, T. Ikeda, H. Tajima, A. Kuroda, Sci. Rep. 2020, 10, 18718.
Y. Wolf, A. C. Anderson, V. K. Kuchroo, Nat. Rev. Immunol. 2020, 20, 173.
Y. Liang, W. S. Eng, D. R. Colquhoun, R. R. Dinglasan, D. R. Graham, L. K. Mahal, J. Biol. Chem. 2014, 289, 32526.
H. Tanaka, M. Kanda, T. Miwa, C. Tanaka, D. Kobayashi, S. Umeda, M. Shibata, M. Suenaga, N. Hattori, M. Hayashi, N. Iwata, S. Yamada, G. Nakayama, M. Fujiwara, Y. Kodera, Mol. Cancer Res. 2018, 16, 1420.
H. Ise, S. Kobayashi, M. Goto, T. Sato, M. Kawakubo, M. Takahashi, U. Ikeda, T. Akaike, Glycobiology 2010, 20, 843.
T. M. Allen, P. R. Cullis, Adv. Drug Delivery Rev. 2013, 65, 36.
Y. Takakura, A. Matsumoto, Y. Takahashi, Biol. Pharm. Bull. 2020, 43, 576.
O. P. Wiklander, J. Z. Nordin, A. O'Loughlin, Y. Gustafsson, G. Corso, I. Mäger, P. Vader, Y. Lee, H. Sork, Y. Seow, J. Extracell. Vesicles 2015, 20, 26316.
J. Wang, A. Hendrix, S. Hernot, M. Lemaire, E. De Bruyne, E. Van Valckenborgh, T. Lahoutte, O. De Wever, K. Vanderkerken, E. Menu, Blood 2014, 124, 555.
C. Grange, M. Tapparo, S. Bruno, D. Chatterjee, P. J. Quesenberry, C. Tetta, G. Camussi, Int. J. Mol. Med. 2014, 33, 1055.
H. Haga, I. K. Yan, K. Takahashi, A. Matsuda, T. Patel, Stem Cells Transl. Med. 2017, 6, 1262.
M. Mendt, S. Kamerkar, H. Sugimoto, K. M. McAndrews, C.-C. Wu, M. Gagea, S. Yang, E. V. R. Blanko, Q. Peng, X. Ma, JCI Insight 2018, 3, e99263.
S. Wen, M. Dooner, E. Papa, M. Del Tatto, M. Pereira, T. Borgovan, Y. Cheng, L. Goldberg, O. Liang, G. Camussi, Int. J. Mol. Sci. 2019, 20, 5468.
J. Wang, C. J. Lee, M. B. Deci, N. Jasiewicz, A. Verma, J. M. Canty, J. Nguyen, Nanomedicine 2020, 27, 102201.
O. Levy, R. Kuai, E. M. Siren, D. Bhere, Y. Milton, N. Nissar, M. De Biasio, M. Heinelt, B. Reeve, R. Abdi, Sci. Adv. 2020, 6, eaba6884.
S. C. Saunderson, A. C. Dunn, P. R. Crocker, A. D. McLellan, Blood 2014, 123, 208.
K. Tanaka, E. R. Siwu, K. Minami, K. Hasegawa, S. Nozaki, Y. Kanayama, K. Koyama, W. C. Chen, J. C. Paulson, Y. Watanabe, Angew. Chem. 2010, 49, 8195.
A. Ogura, S. Urano, T. Tahara, S. Nozaki, R. Sibgatullina, K. Vong, T. Suzuki, N. Dohmae, A. Kurbangalieva, Y. Watanabe, Chem. Commun. 2018, 54, 8693.
T. Metsalu, J. Vilo, Nucleic Acids Res. 2015, 43, W566.