Cyanidin attenuates the apoptosis of rat nucleus pulposus cells and the degeneration of intervertebral disc via the JAK2/STAT3 signal pathway
Animals
Anthocyanins
/ administration & dosage
Apoptosis
/ drug effects
Dose-Response Relationship, Drug
Inhibitory Concentration 50
Interleukin-1beta
/ administration & dosage
Intervertebral Disc Degeneration
/ prevention & control
Janus Kinase 2
/ metabolism
Male
Nucleus Pulposus
/ drug effects
Rats
Rats, Sprague-Dawley
STAT3 Transcription Factor
/ metabolism
Signal Transduction
/ drug effects
Extracellular matrix degeneration
autophagy
chloroquine
natural polyphenolic compounds
Journal
Pharmaceutical biology
ISSN: 1744-5116
Titre abrégé: Pharm Biol
Pays: England
ID NLM: 9812552
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
entrez:
17
2
2022
pubmed:
18
2
2022
medline:
11
3
2022
Statut:
ppublish
Résumé
Cyanidin has been shown to have therapeutic potential in osteoarthritis. However, it is unclear whether cyanidin prevents the progression of intervertebral disc degeneration (IVDD). This study evaluates the effects of cyanidin on IVDD Nucleus pulposus cells (NPCs) isolated from lumbar IVD of 4-week-old male Sprague-Dawley (SD) rats were exposed to 20 ng/mL IL-1β, and then treated with different doses (0-120 µM) of cyanidin for 24 h. SD rats were classified into three groups ( The IC Cyanidin improved the function of NPCs in IVDD by regulating the JAK2/STAT3 pathway, which may provide a novel alternative strategy for IVDD. The mechanism of cyanidin improving IVDD still needs further work for in-depth investigation.
Identifiants
pubmed: 35175176
doi: 10.1080/13880209.2022.2035773
pmc: PMC8856032
doi:
Substances chimiques
Anthocyanins
0
Interleukin-1beta
0
STAT3 Transcription Factor
0
Stat3 protein, rat
0
cyanidin
7732ZHU564
Jak2 protein, rat
EC 2.7.10.2
Janus Kinase 2
EC 2.7.10.2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
427-436Références
Acta Neurochir (Wien). 2010 Oct;152(10):1771-7
pubmed: 20571835
Cell Death Dis. 2014 Feb 27;5:e1088
pubmed: 24577086
Spine (Phila Pa 1976). 2017 Jul 15;42(14):E817-E824
pubmed: 27879577
Food Funct. 2017 Nov 15;8(11):4089-4099
pubmed: 28990610
FASEB J. 2019 Jul;33(7):8008-8021
pubmed: 30913399
Int J Biol Sci. 2018 Apr 30;14(6):682-692
pubmed: 29904282
Cell Death Differ. 2010 Feb;17(2):268-77
pubmed: 19713971
Pharm Biol. 2019 Dec;57(1):625-631
pubmed: 31545912
Clin Chim Acta. 2015 Aug 25;448:238-46
pubmed: 26162271
Nat Rev Mol Cell Biol. 2018 Feb;19(2):121-135
pubmed: 28974774
Sci Rep. 2014 Dec 12;4:7456
pubmed: 25503852
Food Funct. 2019 Sep 1;10(9):5873-5885
pubmed: 31464310
Exp Ther Med. 2017 Aug;14(2):1131-1135
pubmed: 28810568
Evid Based Complement Alternat Med. 2017;2017:2198323
pubmed: 29259641
J Cell Physiol. 2020 Feb;235(2):1780-1794
pubmed: 31317559
Spine (Phila Pa 1976). 2008 Nov 15;33(24):2586-95
pubmed: 19011540
Eur Spine J. 2019 Sep;28(9):2129-2144
pubmed: 31201565
Cell Biol Toxicol. 2003 Aug;19(4):243-52
pubmed: 14686616
Cell Physiol Biochem. 2018;46(6):2517-2531
pubmed: 29742507
Biofactors. 2016 Mar-Apr;42(2):212-23
pubmed: 26879681
Theranostics. 2019 Apr 12;9(8):2252-2267
pubmed: 31149042
Mol Med Rep. 2015 Aug;12(2):1761-8
pubmed: 25892402
Am J Chin Med. 2018 Oct 4;:1-20
pubmed: 30284462
Cell Death Dis. 2018 Jan 19;9(2):56
pubmed: 29352194
Food Chem Toxicol. 2018 Oct;120:104-111
pubmed: 29803697
Nanoscale. 2019 Jun 20;11(24):11605-11616
pubmed: 31173033
Cell Mol Life Sci. 2018 Jul;75(13):2389-2406
pubmed: 29675785
Int J Ophthalmol. 2019 Sep 18;12(9):1395-1401
pubmed: 31544032
Iran J Basic Med Sci. 2016 Aug;19(8):812-820
pubmed: 27746861
Spine (Phila Pa 1976). 2015 May 1;40(9):E515-24
pubmed: 25646749
Gene. 2017 Sep 10;628:259-266
pubmed: 28716711
Redox Biol. 2018 Sep;18:16-24
pubmed: 29890336
Nat Cell Biol. 2006 Oct;8(10):1124-32
pubmed: 16998475
Acta Pharmacol Sin. 2018 Sep;39(9):1439-1452
pubmed: 29671417
Exp Ther Med. 2018 Feb;15(2):1959-1965
pubmed: 29434790
Exp Biol Med (Maywood). 2016 Apr;241(8):848-53
pubmed: 26946533
Mol Cell. 2012 Dec 14;48(5):667-80
pubmed: 23084476
Cancer Lett. 2013 Jun 1;333(1):36-46
pubmed: 23360684
Biosci Rep. 2018 Jul 6;38(4):
pubmed: 29752339
World J Gastroenterol. 2015 Jun 28;21(24):7468-77
pubmed: 26139992
Aging (Albany NY). 2018 Jan 18;10(1):131-143
pubmed: 29348392
Eur Cell Mater. 2017 Mar 24;33:240-251
pubmed: 28345732
FASEB J. 2019 Oct;33(10):11555-11566
pubmed: 31331201
J Pineal Res. 2015 Oct;59(3):292-307
pubmed: 26201382
Phytomedicine. 2019 Feb;53:86-95
pubmed: 30668416
Stem Cell Res Ther. 2015 Dec 15;6:247
pubmed: 26670667
Front Physiol. 2020 Aug 12;11:988
pubmed: 32903465