Folate Deficiency: A Possible Association with Congenital Heart Defects.
Children
Congenital heart defects
Folate
India
Vitamin B12
Journal
Indian journal of pediatrics
ISSN: 0973-7693
Titre abrégé: Indian J Pediatr
Pays: India
ID NLM: 0417442
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
received:
10
08
2021
accepted:
24
11
2021
pubmed:
18
2
2022
medline:
21
9
2022
entrez:
17
2
2022
Statut:
ppublish
Résumé
Congenital heart defects continue to remain a major cause of serious morbidity and mortality, especially in the developing world. This study was planned to get some insight into the role of modifiable nutritional elements in structural CHD etiology. This cross-sectional, observational study was conducted at a hospital in Northern India from January 2017 to December 2017. Infants < 6 mo with structural CHD as cases and those without structural heart disease were enrolled as controls. Blood samples were collected from mother-child pairs and tested for serum folate, vitamin B12, and homocysteine. It was found that 46.7% infant-mother pairs, out of 45 in the cases group had folate deficiency, whereas in the control group, only 20% had folate deficiency, which was statistically significant (p = 0.013). Baby (0-6 mo) with congenital heart defects (CHD) and their mothers are more likely to have low folate levels compared to those not having CHD.
Identifiants
pubmed: 35175552
doi: 10.1007/s12098-022-04125-z
pii: 10.1007/s12098-022-04125-z
doi:
Substances chimiques
Homocysteine
0LVT1QZ0BA
Folic Acid
935E97BOY8
Vitamin B 12
P6YC3EG204
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1013-1015Informations de copyright
© 2022. Dr. K C Chaudhuri Foundation.
Références
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