Mucosal fungi promote gut barrier function and social behavior via Type 17 immunity.
Th17
fungal consortia
gut-brain axis
intestinal barrier
microbiota biogeography
mycobiome
mycobiota
neuroimmune interactions
social behavior
Journal
Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066
Informations de publication
Date de publication:
03 03 2022
03 03 2022
Historique:
received:
06
12
2019
revised:
30
11
2021
accepted:
20
01
2022
pubmed:
18
2
2022
medline:
26
4
2022
entrez:
17
2
2022
Statut:
ppublish
Résumé
Fungal communities (the mycobiota) are an integral part of the gut microbiota, and the disruption of their integrity contributes to local and gut-distal pathologies. Yet, the mechanisms by which intestinal fungi promote homeostasis remain unclear. We characterized the mycobiota biogeography along the gastrointestinal tract and identified a subset of fungi associated with the intestinal mucosa of mice and humans. Mucosa-associated fungi (MAF) reinforced intestinal epithelial function and protected mice against intestinal injury and bacterial infection. Notably, intestinal colonization with a defined consortium of MAF promoted social behavior in mice. The gut-local effects on barrier function were dependent on IL-22 production by CD4
Identifiants
pubmed: 35176228
pii: S0092-8674(22)00075-7
doi: 10.1016/j.cell.2022.01.017
pmc: PMC8897247
mid: NIHMS1774356
pii:
doi:
Substances chimiques
Il17ra protein, mouse
0
Receptors, Interleukin-17
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
831-846.e14Subventions
Organisme : NIAID NIH HHS
ID : R01 AI163007
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK113136
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK121977
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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