Primary malignant peripheral nerve sheath tumors of bone: a clinicopathologic reappraisal of 8 cases.
Bone
MPNST
Pleomorphic sarcoma
Primary bone sarcomas
Spindle cell sarcoma
Journal
Human pathology
ISSN: 1532-8392
Titre abrégé: Hum Pathol
Pays: United States
ID NLM: 9421547
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
07
01
2022
revised:
07
02
2022
accepted:
07
02
2022
pubmed:
18
2
2022
medline:
6
4
2022
entrez:
17
2
2022
Statut:
ppublish
Résumé
Primary spindle cell and pleomorphic sarcomas of bone represent an exceedingly rare group of mesenchymal malignancies that include soft tissue histotypes, as malignant peripheral nerve sheath tumor. Outside the head and neck region, only 36 cases of primary malignant peripheral nerve sheath tumor of bone have been described. We retrieved from our archives eight cases of primary malignant peripheral nerve sheath tumor of bone arising outside the head and neck region, describing their clinical, radiological, and morphologic features. Our series, in which all but one patient died of diseases after a median of seven months, confirms that primary malignant peripheral nerve sheath tumors of bone are aggressive tumors. Pathologists should be aware of this rare histotype. More aggressive and active adjuvant treatments should be investigated.
Identifiants
pubmed: 35176251
pii: S0046-8177(22)00031-4
doi: 10.1016/j.humpath.2022.02.003
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
92-102Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.