Characterization of novel nonacid glycosphingolipids as biomarkers of human gastric adenocarcinoma.
H. pylori binding
P1 glycosphingolipid
gastric adenocarcinoma
glycosphingolipid characterization
mass spectrometry
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
20
12
2021
revised:
11
02
2022
accepted:
12
02
2022
pubmed:
18
2
2022
medline:
27
4
2022
entrez:
17
2
2022
Statut:
ppublish
Résumé
Changes in glycosphingolipid structures have been shown to occur during the development of several types of human cancers, generating cancer-specific carbohydrate structures that could be used as biomarkers for diagnosis and therapeutic targeting. In this study, we characterized nonacid glycosphingolipids isolated from a human gastric adenocarcinoma by mass spectrometry, enzymatic hydrolysis, and by binding with a battery of carbohydrate-recognizing ligands. We show that the majority of the complex nonacid glycosphingolipids had type 2 (Galβ4GlcNAc) core chains (neolactotetraosylceramide, the Le
Identifiants
pubmed: 35176282
pii: S0021-9258(22)00172-7
doi: 10.1016/j.jbc.2022.101732
pmc: PMC8933711
pii:
doi:
Substances chimiques
Biomarkers
0
Carbohydrates
0
Glycosphingolipids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101732Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest The authors declare that they have no conflicts of interest with the contents of this article.