Novel D
1,4-Di-substituted aromatic piperazines
Antipsychotic
Aripiprazole
Cariprazine
Dopamine type 2 receptor
Drug development
Schizophrenia
Serotonin receptor type 3
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
15 Mar 2022
15 Mar 2022
Historique:
received:
03
01
2022
revised:
28
01
2022
accepted:
08
02
2022
pubmed:
18
2
2022
medline:
17
3
2022
entrez:
17
2
2022
Statut:
ppublish
Résumé
Schizophrenia is a serious mental disorder without a fully understood pathomechanism, but which involves dysregulation of neurotransmitters and their receptors. The best option for the management of schizophrenia comprises so-called multi-target ligands, similar to the third generation of neuroleptics. Dopamine type 2 receptors (D
Identifiants
pubmed: 35176563
pii: S0223-5234(22)00095-2
doi: 10.1016/j.ejmech.2022.114193
pii:
doi:
Substances chimiques
Antipsychotic Agents
0
Piperazines
0
Receptors, Serotonin
0
cariprazine
F6RJL8B278
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
114193Informations de copyright
Copyright © 2022 Elsevier Masson SAS. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.