Melatonin as a Chronobiotic with Sleep-promoting Properties.
Melatonin
chronobiotic
circadian rhythm sleep disorders
hypnotic
insomnia
sleep-inducing
sleep-promoting
soporific
Journal
Current neuropharmacology
ISSN: 1875-6190
Titre abrégé: Curr Neuropharmacol
Pays: United Arab Emirates
ID NLM: 101157239
Informations de publication
Date de publication:
2023
2023
Historique:
received:
23
12
2021
revised:
26
01
2022
accepted:
10
02
2022
medline:
22
5
2023
pubmed:
19
2
2022
entrez:
18
2
2022
Statut:
ppublish
Résumé
The use of exogenous melatonin (exo-MEL) as a sleep-promoting drug has been under extensive debate due to the lack of consistency of its described effects. In this study, we conduct a systematic and comprehensive review of the literature on the chronobiotic, sleep-inducing, and overall sleep-promoting properties of exo-MEL. To this aim, we first describe the possible pharmacological mechanisms involved in the sleep-promoting properties and then report the corresponding effects of exo-MEL administration on clinical outcomes in: a) healthy subjects, b) circadian rhythm sleep disorders, c) primary insomnia. Timing of administration and doses of exo-MEL received particular attention in this work. The exo-MEL pharmacological effects are hereby interpreted in view of changes in the physiological properties and rhythmicity of endogenous melatonin. Finally, we discuss some translational implications for the personalized use of exo-MEL in the clinical practice.
Identifiants
pubmed: 35176989
pii: CN-EPUB-120990
doi: 10.2174/1570159X20666220217152617
pmc: PMC10227911
doi:
Substances chimiques
Melatonin
JL5DK93RCL
Types de publication
Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
951-987Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
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