Clinical and Epidemiological Features of Patients with Drug-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Iran: Different Points of Children from Adults.
Journal
International journal of pediatrics
ISSN: 1687-9740
Titre abrégé: Int J Pediatr
Pays: Egypt
ID NLM: 101517077
Informations de publication
Date de publication:
2022
2022
Historique:
received:
21
09
2021
revised:
25
12
2021
accepted:
19
01
2022
entrez:
18
2
2022
pubmed:
19
2
2022
medline:
19
2
2022
Statut:
epublish
Résumé
Different epidemiologic aspects of drug-induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in children are scarce. To compare the clinical and epidemiological features of patients with drug-induced SJS and TEN in children and adults. This retrospective study was conducted at two academic referral centers (Isfahan, Iran) over 5 years. SJS and TEN were clinically diagnosed and confirmed by skin biopsy as needed. One hundred one patients (31 children and 70 adults) with a female to male ratio of 1.1 : 1 was identified in the present study. SJS was more commonly diagnosed in both pediatric and adult patients. The most frequent reason for drug administration identified was the infection (45.2%) and seizure (45.2%) in children and infection (34.3%) and psychiatry disorder (27.1%) in adults ( The present study showed several differences between the pediatric and adult patients with SJS and TEN, including the reason for drug administration, culprit drugs, length of hospital stay, presence of fever, and final diagnosis of disease.
Sections du résumé
BACKGROUND
BACKGROUND
Different epidemiologic aspects of drug-induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in children are scarce.
AIM
OBJECTIVE
To compare the clinical and epidemiological features of patients with drug-induced SJS and TEN in children and adults.
METHOD
METHODS
This retrospective study was conducted at two academic referral centers (Isfahan, Iran) over 5 years. SJS and TEN were clinically diagnosed and confirmed by skin biopsy as needed.
RESULTS
RESULTS
One hundred one patients (31 children and 70 adults) with a female to male ratio of 1.1 : 1 was identified in the present study. SJS was more commonly diagnosed in both pediatric and adult patients. The most frequent reason for drug administration identified was the infection (45.2%) and seizure (45.2%) in children and infection (34.3%) and psychiatry disorder (27.1%) in adults (
CONCLUSIONS
CONCLUSIONS
The present study showed several differences between the pediatric and adult patients with SJS and TEN, including the reason for drug administration, culprit drugs, length of hospital stay, presence of fever, and final diagnosis of disease.
Identifiants
pubmed: 35178096
doi: 10.1155/2022/8163588
pmc: PMC8847037
doi:
Types de publication
Journal Article
Langues
eng
Pagination
8163588Informations de copyright
Copyright © 2022 Bahareh Abtahi-Naeini et al.
Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest regarding the publication of this paper.
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