Imaging Net Retrograde Axonal Transport In Vivo: A Physiological Biomarker.
Journal
Annals of neurology
ISSN: 1531-8249
Titre abrégé: Ann Neurol
Pays: United States
ID NLM: 7707449
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
revised:
06
02
2022
received:
24
11
2021
accepted:
14
02
2022
pubmed:
19
2
2022
medline:
20
4
2022
entrez:
18
2
2022
Statut:
ppublish
Résumé
The objective of this study is to develop a novel method for monitoring the integrity of motor neurons in vivo by quantifying net retrograde axonal transport. The method uses single photon emission computed tomography to quantify retrograde transport to spinal cord of tetanus toxin fragment C ( This technique defines a quantitative profile of net retrograde axonal transport of TTC in living mice. The profile is distinctly abnormal in transgenic SOD1 This assay of net retrograde axonal transport has broad potential clinical applications and should be particularly valuable as a physiological biomarker that permits early detection of benefit from potential therapies for motor neuron diseases. ANN NEUROL 2022;91:716-729.
Identifiants
pubmed: 35178738
doi: 10.1002/ana.26329
pmc: PMC9313858
doi:
Substances chimiques
Biomarkers
0
PFN1 protein, human
0
Profilins
0
Tetanus Toxoid
0
Superoxide Dismutase
EC 1.15.1.1
Superoxide Dismutase-1
EC 1.15.1.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
716-729Subventions
Organisme : NIH HHS
ID : RO1-NS088689
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001453
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS118145
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS088689
Pays : United States
Organisme : NIH HHS
ID : UL1-TR001453
Pays : United States
Organisme : NIH HHS
ID : 5R01NS101895
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS101895
Pays : United States
Informations de copyright
© 2022 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.
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