Oncologic impact of concomitant prostate cancer characteristics at the time of radical cystoprostatectomy for bladder cancer: a population-based analysis.


Journal

The aging male : the official journal of the International Society for the Study of the Aging Male
ISSN: 1473-0790
Titre abrégé: Aging Male
Pays: England
ID NLM: 9808210

Informations de publication

Date de publication:
Dec 2022
Historique:
entrez: 18 2 2022
pubmed: 19 2 2022
medline: 22 2 2022
Statut: ppublish

Résumé

The aim of this study was to evaluate the prognostic impact of concomitant prostate cancer (PCa) of the cancer-specific mortality (CSM) in the aging patient's papulation with bladder cancer (BCa) treated with radical cystoprostatectomy (RCP). Within the SEER database (2004-2015), 1468 patients were treated with RCP for BCa harboring histopathological PCa findings. To account for other cause mortality (OCM), multivariable competing risk regression (CRR) tested for potential BCa-CSM differences according to PCa characteristics risk factors predicting CSM. CRR analysis revealed that only following BCa characteristics, as high pathological tumor stages(Ta/Tis/T1 [REF.] vs. T2; HR 2.03, 95% CI: 1.16-3.57, Our study, based on the largest population cohort, demonstrates that even in organ-confined BCa patients, concomitant PCa as second malignancy does not represent a risk factor for survival.

Identifiants

pubmed: 35179092
doi: 10.1080/13685538.2022.2040982
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

54-61

Auteurs

Mykyta Kachanov (M)

Martini-Klinik, Prostate Cancer Center Hamburg-Eppendorf, Hamburg, Germany.
Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Malte W Vetterlein (MW)

Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Armin Soave (A)

Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Pierre I Karakiewicz (PI)

Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montreal Health Center, Montreal, Canada.

Nikolaos Liakos (N)

Prostate Center Northwest, Department of Urology, Paediatric Urology and Uro-Oncology, St. Antonius-Hospital, Gronau, Germany.

Thomas Jankowski (T)

Prostate Center Northwest, Department of Urology, Paediatric Urology and Uro-Oncology, St. Antonius-Hospital, Gronau, Germany.

Randi M Pose (RM)

Martini-Klinik, Prostate Cancer Center Hamburg-Eppendorf, Hamburg, Germany.

Mikolaj Mandrek (M)

Prostate Center Northwest, Department of Urology, Paediatric Urology and Uro-Oncology, St. Antonius-Hospital, Gronau, Germany.

Margit Fisch (M)

Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Jorn H Witt (JH)

Prostate Center Northwest, Department of Urology, Paediatric Urology and Uro-Oncology, St. Antonius-Hospital, Gronau, Germany.

Markus Graefen (M)

Martini-Klinik, Prostate Cancer Center Hamburg-Eppendorf, Hamburg, Germany.

Sami-Ramzi Leyh-Bannurah (SR)

Prostate Center Northwest, Department of Urology, Paediatric Urology and Uro-Oncology, St. Antonius-Hospital, Gronau, Germany.

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Classifications MeSH