Comparison of short-term outcomes from the International Oesophago-Gastric Anastomosis Audit (OGAA), the Esophagectomy Complications Consensus Group (ECCG), and the Dutch Upper Gastrointestinal Cancer Audit (DUCA).
Journal
BJS open
ISSN: 2474-9842
Titre abrégé: BJS Open
Pays: England
ID NLM: 101722685
Informations de publication
Date de publication:
07 05 2021
07 05 2021
Historique:
received:
15
12
2020
accepted:
27
01
2021
entrez:
18
2
2022
pubmed:
19
2
2022
medline:
24
3
2022
Statut:
ppublish
Résumé
The Esophagectomy Complications Consensus Group (ECCG) and the Dutch Upper Gastrointestinal Cancer Audit (DUCA) have set standards in reporting outcomes after oesophagectomy. Reporting outcomes from selected high-volume centres or centralized national cancer programmes may not, however, be reflective of the true global prevalence of complications. This study aimed to compare complication rates after oesophagectomy from these existing sources with those of an unselected international cohort from the Oesophago-Gastric Anastomosis Audit (OGAA). The OGAA was a prospective multicentre cohort study coordinated by the West Midlands Research Collaborative, and included patients undergoing oesophagectomy for oesophageal cancer between April and December 2018, with 90 days of follow-up. The OGAA study included 2247 oesophagectomies across 137 hospitals in 41 countries. Comparisons with the ECCG and DUCA found differences in baseline demographics between the three cohorts, including age, ASA grade, and rates of chronic pulmonary disease. The OGAA had the lowest rates of neoadjuvant treatment (OGAA 75.1 per cent, ECCG 78.9 per cent, DUCA 93.5 per cent; P < 0.001). DUCA exhibited the highest rates of minimally invasive surgery (OGAA 57.2 per cent, ECCG 47.9 per cent, DUCA 85.8 per cent; P < 0.001). Overall complication rates were similar in the three cohorts (OGAA 63.6 per cent, ECCG 59.0 per cent, DUCA 62.2 per cent), with no statistically significant difference in Clavien-Dindo grades (P = 0.752). However, a significant difference in 30-day mortality was observed, with DUCA reporting the lowest rate (OGAA 3.2 per cent, ECCG 2.4 per cent, DUCA 1.7 per cent; P = 0.013). Despite differences in rates of co-morbidities, oncological treatment strategies, and access to minimal-access surgery, overall complication rates were similar in the three cohorts.
Sections du résumé
BACKGROUND
The Esophagectomy Complications Consensus Group (ECCG) and the Dutch Upper Gastrointestinal Cancer Audit (DUCA) have set standards in reporting outcomes after oesophagectomy. Reporting outcomes from selected high-volume centres or centralized national cancer programmes may not, however, be reflective of the true global prevalence of complications. This study aimed to compare complication rates after oesophagectomy from these existing sources with those of an unselected international cohort from the Oesophago-Gastric Anastomosis Audit (OGAA).
METHODS
The OGAA was a prospective multicentre cohort study coordinated by the West Midlands Research Collaborative, and included patients undergoing oesophagectomy for oesophageal cancer between April and December 2018, with 90 days of follow-up.
RESULTS
The OGAA study included 2247 oesophagectomies across 137 hospitals in 41 countries. Comparisons with the ECCG and DUCA found differences in baseline demographics between the three cohorts, including age, ASA grade, and rates of chronic pulmonary disease. The OGAA had the lowest rates of neoadjuvant treatment (OGAA 75.1 per cent, ECCG 78.9 per cent, DUCA 93.5 per cent; P < 0.001). DUCA exhibited the highest rates of minimally invasive surgery (OGAA 57.2 per cent, ECCG 47.9 per cent, DUCA 85.8 per cent; P < 0.001). Overall complication rates were similar in the three cohorts (OGAA 63.6 per cent, ECCG 59.0 per cent, DUCA 62.2 per cent), with no statistically significant difference in Clavien-Dindo grades (P = 0.752). However, a significant difference in 30-day mortality was observed, with DUCA reporting the lowest rate (OGAA 3.2 per cent, ECCG 2.4 per cent, DUCA 1.7 per cent; P = 0.013).
CONCLUSION
Despite differences in rates of co-morbidities, oncological treatment strategies, and access to minimal-access surgery, overall complication rates were similar in the three cohorts.
Identifiants
pubmed: 35179183
pii: 6530583
doi: 10.1093/bjsopen/zrab010
pmc: PMC8140199
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Cancer Research UK
ID : 23924
Pays : United Kingdom
Investigateurs
J Fergusson
(J)
E Beenen
(E)
C Mosse
(C)
J Salim
(J)
S Cheah
(S)
T Wright
(T)
M P Cerdeira
(MP)
P McQuillan
(P)
M Richardson
(M)
H Liem
(H)
J Spillane
(J)
M Yacob
(M)
F Albadawi
(F)
T Thorpe
(T)
A Dingle
(A)
C Cabalag
(C)
K Loi
(K)
O M Fisher
(OM)
S Ward
(S)
M Read
(M)
M Johnson
(M)
R Bassari
(R)
H Bui
(H)
I Cecconello
(I)
Raa Sallum
(R)
Jrm da Rocha
(J)
L R Lopes
(LR)
V Tercioti
(V)
Jds Coelho
(J)
Jap Ferrer
(J)
G Buduhan
(G)
L Tan
(L)
S Srinathan
(S)
P Shea
(P)
J Yeung
(J)
F Allison
(F)
P Carroll
(P)
F Vargas-Barato
(F)
F Gonzalez
(F)
J Ortega
(J)
L Nino-Torres
(L)
T C Beltrán-García
(TC)
L Castilla
(L)
M Pineda
(M)
A Bastidas
(A)
J Gómez-Mayorga
(J)
N Cortés
(N)
C Cetares
(C)
S Caceres
(S)
S Duarte
(S)
A Pazdro
(A)
M Snajdauf
(M)
H Faltova
(H)
M Sevcikova
(M)
P B Mortensen
(PB)
N Katballe
(N)
T Ingemann
(T)
B Morten
(B)
I Kruhlikava
(I)
A P Ainswort
(AP)
N M Stilling
(NM)
J Eckardt
(J)
J Holm
(J)
M Thorsteinsson
(M)
M Siemsen
(M)
B Brandt
(B)
B Nega
(B)
E Teferra
(E)
A Tizazu
(A)
J S Kauppila
(JS)
V Koivukangas
(V)
S Meriläinen
(S)
R Gruetzmann
(R)
C Krautz
(C)
G Weber
(G)
H Golcher
(H)
G Emons
(G)
A Azizian
(A)
M Ebeling
(M)
S Niebisch
(S)
N Kreuser
(N)
G Albanese
(G)
J Hesse
(J)
L Volovnik
(L)
U Boecher
(U)
M Reeh
(M)
S Triantafyllou
(S)
D Schizas
(D)
A Michalinos
(A)
E Mpali
(E)
M Mpoura
(M)
A Charalabopoulos
(A)
D K Manatakis
(DK)
D Balalis
(D)
J Bolger
(J)
C Baban
(C)
A Mastrosimone
(A)
O McAnena
(O)
A Quinn
(A)
C B Ó Súilleabháin
(CB)
M M Hennessy
(MM)
I Ivanovski
(I)
H Khizer
(H)
N Ravi
(N)
N Donlon
(N)
M Cervellera
(M)
S Vaccari
(S)
S Bianchini
(S)
L Sartarelli
(L)
E Asti
(E)
D Bernardi
(D)
S Merigliano
(S)
L Provenzano
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M Scarpa
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L Saadeh
(L)
B Salmaso
(B)
G De Manzoni
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(S)
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T Irino
(T)
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(R)
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(K)
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(M)
A Fekadu
(A)
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(A)
E Mwachiro
(E)
D AlShehab
(D)
H A Ahmed
(HA)
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(AO)
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(A)
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(FA)
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(HF)
S T Makkai-Popa
(ST)
L F Wong
(LF)
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(T)
S Thanninalai
(S)
H C Aik
(HC)
P W Soon
(PW)
T J Huei
(TJ)
Hnl Basave
(H)
R Cortés-González
(R)
S M Lagarde
(SM)
Jjb van Lanschot
(J)
C Cords
(C)
W A Jansen
(WA)
I Martijnse
(I)
R Matthijsen
(R)
S Bouwense
(S)
B Klarenbeek
(B)
M Verstegen
(M)
F van Workum
(F)
J P Ruurda
(JP)
P C van der Sluis
(PC)
M de Maat
(M)
N Evenett
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P Johnston
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R Patel
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A MacCormick
(A)
M Young
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B Smith
(B)
C Ekwunife
(C)
A H Memon
(AH)
K Shaikh
(K)
A Wajid
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N Khalil
(N)
M Haris
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Z U Mirza
(ZU)
Sba Qudus
(S)
M Z Sarwar
(MZ)
A Shehzadi
(A)
A Raza
(A)
M H Jhanzaib
(MH)
J Farmanali
(J)
Z Zakir
(Z)
O Shakeel
(O)
I Nasir
(I)
S Khattak
(S)
M Baig
(M)
M A Noor
(MA)
H H Ahmed
(HH)
A Naeem
(A)
A C Pinho
(AC)
R da Silva
(R)
H Matos
(H)
T Braga
(T)
C Monteiro
(C)
P Ramos
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F Cabral
(F)
M P Gomes
(MP)
P C Martins
(PC)
A M Correia
(AM)
J F Videira
(JF)
C Ciuce
(C)
R Drasovean
(R)
R Apostu
(R)
C Ciuce
(C)
S Paitici
(S)
A E Racu
(AE)
C V Obleaga
(CV)
M Beuran
(M)
B Stoica
(B)
C Ciubotaru
(C)
V Negoita
(V)
I Cordos
(I)
R D Birla
(RD)
D Predescu
(D)
P A Hoara
(PA)
R Tomsa
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V Shneider
(V)
M Agasiev
(M)
I Ganjara
(I)
D Gunjic
(D)
M Veselinovic
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T Babič
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(TS)
A Shabbir
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(G)
A Crnjac
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H Samo
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I Díez Del Val
(I)
S Leturio
(S)
I Díez Del Val
(I)
S Leturio
(S)
J M Ramón
(JM)
M Dal Cero
(M)
S Rifá
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M Rico
(M)
A Pagan Pomar
(A)
J A Martinez Corcoles
(JA)
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(JL)
S A Pais
(SA)
S A Turienzo
(SA)
L S Alvarez
(LS)
P V Campos
(PV)
A G Rendo
(AG)
S S García
(SS)
Epg Santos
(E)
E T Martínez
(ET)
M J Fernández Díaz
(MJ)
C Magadán Álvarez
(C)
V Concepción Martín
(V)
C Díaz López
(C)
A Rosat Rodrigo
(A)
L E Pérez Sánchez
(LE)
M Bailón Cuadrado
(M)
C Tinoco Carrasco
(C)
E Choolani Bhojwani
(E)
D P Sánchez
(DP)
M E Ahmed
(ME)
T Dzhendov
(T)
F Lindberg
(F)
M Rutegård
(M)
M Sundbom
(M)
C Mickael
(C)
N Colucci
(N)
A Schnider
(A)
S Er
(S)
E Kurnaz
(E)
S Turkyilmaz
(S)
A Turkyilmaz
(A)
R Yildirim
(R)
B E Baki
(BE)
N Akkapulu
(N)
O Karahan
(O)
N Damburaci
(N)
R Hardwick
(R)
P Safranek
(P)
V Sujendran
(V)
J Bennett
(J)
Z Afzal
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M Shrotri
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T Gilbert
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D Mukherjee
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T H Wiggins
(TH)
R Kennedy
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S McCain
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A Harris
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G Dobson
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N Davies
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I Wilson
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D Mayo
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D Bennett
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R Young
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M Schiller
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B Byrne
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D Mitton
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V Wong
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A Elshaer
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M Cowen
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V Menon
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L C Tan
(LC)
E McLaughlin
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R Koshy
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C Sharp
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H Brewer
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N Das
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M Cox
(M)
W Al Khyatt
(W)
D Worku
(D)
R Iqbal
(R)
L Walls
(L)
R McGregor
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G Fullarton
(G)
A Macdonald
(A)
C MacKay
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C Craig
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S Dwerryhouse
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S Hornby
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S Jaunoo
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M Wadley
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C Baker
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M Saad
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M Kelly
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A Davies
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F Di Maggio
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S McKay
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P Mistry
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R Singhal
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O Tucker
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S Kapoulas
(S)
S Powell-Brett
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P Davis
(P)
G Bromley
(G)
L Watson
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R Verma
(R)
J Ward
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V Shetty
(V)
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(C)
K Pursnani
(K)
A Sarela
(A)
H Sue Ling
(H)
S Mehta
(S)
J Hayden
(J)
N To
(N)
T Palser
(T)
D Hunter
(D)
K Supramaniam
(K)
Z Butt
(Z)
A Ahmed
(A)
S Kumar
(S)
A Chaudry
(A)
O Moussa
(O)
A Kordzadeh
(A)
B Lorenzi
(B)
J Willem
(J)
G Bouras
(G)
R Evans
(R)
M Singh
(M)
H Warrilow
(H)
A Ahmad
(A)
N Tewari
(N)
F Yanni
(F)
J Couch
(J)
E Theophilidou
(E)
J J Reilly
(JJ)
P Singh
(P)
Gijs van Boxel
(G)
K Akbari
(K)
D Zanotti
(D)
B Sgromo
(B)
G Sanders
(G)
T Wheatley
(T)
A Ariyarathenam
(A)
A Reece-Smith
(A)
L Humphreys
(L)
C Choh
(C)
N Carter
(N)
B Knight
(B)
P Pucher
(P)
A Athanasiou
(A)
I Mohamed
(I)
B Tan
(B)
M Abdulrahman
(M)
J Vickers
(J)
K Akhtar
(K)
R Chaparala
(R)
R Brown
(R)
Mma Alasmar
(M)
R Ackroyd
(R)
K Patel
(K)
A Tamhankar
(A)
A Wyman
(A)
R Walker
(R)
B Grace
(B)
N Abbassi
(N)
N Slim
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L Ioannidi
(L)
G Blackshaw
(G)
T Havard
(T)
X Escofet
(X)
A Powell
(A)
A Owera
(A)
F Rashid
(F)
P Jambulingam
(P)
J Padickakudi
(J)
H Ben-Younes
(H)
K Mccormack
(K)
I A Makey
(IA)
M K Karush
(MK)
C W Seder
(CW)
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(MJ)
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(JD)
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of BJS Society Ltd.
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