[The importance of telomeres in human herpesvirus-6A/B infections].
L’importance des télomères dans les infections par les Herpèsvirus humains-6A/B.
Journal
Medecine sciences : M/S
ISSN: 1958-5381
Titre abrégé: Med Sci (Paris)
Pays: France
ID NLM: 8710980
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
entrez:
18
2
2022
pubmed:
19
2
2022
medline:
7
4
2022
Statut:
ppublish
Résumé
Herpesviruses are undisputed masters of disguise. The ability to become invisible to the immune system effectors is a complex process resting on a variety of stealth approaches. Among these, human herpesviruses-6A and -6B (HHV-6A/B) have developed the unique ability to integrate their genome within the ends of chromosomes allowing viral persistence in the absence of viral protein expression. This aptitude, unique to HHV-6A/B among human herpesviruses, requires close interactions between the telomeric regions of chromosomes and the viral genome. In this review article, the biology of telomeres and the mechanisms responsible for viral integration are discussed. In closing, the possible biological consequences of HHV-6A/B integration into chromosomal DNA are discussed. L’importance des télomères dans les infections par les Herpèsvirus humains-6A/B. Les Herpèsvirus sont des maîtres incontestés du camouflage. En effet, ces virus utilisent divers moyens pour assurer leur persistance chez l’hôte infecté. Les Herpèsvirus humains-6A et -6B (HHV-6A/B) ont ainsi développé une approche unique, en intégrant l’ensemble de leur génome au sein des extrémités des chromosomes des cellules qu’ils infectent. Cette capacité, propre aux HHV-6A/B parmi les Herpèsvirus humains, requiert des interactions étroites entre les régions télomériques des chromosomes de l’hôte et le génome viral. Dans cette revue, la biologie des télomères et les mécanismes responsables de l’intégration virale seront abordés et les conséquences biologiques de l’intégration des HHV-6A/B au sein de l’ADN chromosomique seront discutées.
Autres résumés
Type: Publisher
(fre)
L’importance des télomères dans les infections par les Herpèsvirus humains-6A/B.
Identifiants
pubmed: 35179471
doi: 10.1051/medsci/2022008
pii: msc200485
doi:
Types de publication
Journal Article
Review
Langues
fre
Sous-ensembles de citation
IM
Pagination
168-176Informations de copyright
© 2022 médecine/sciences – Inserm.
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