Sex differences and sex bias in human circadian and sleep physiology research.
chronobiology
circadian physiology
equality diversity inclusion
human
science forum
sex differences
sleep
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
18 02 2022
18 02 2022
Historique:
received:
03
12
2020
accepted:
18
02
2022
pubmed:
19
2
2022
medline:
5
4
2022
entrez:
18
2
2022
Statut:
epublish
Résumé
Growing evidence shows that sex differences impact many facets of human biology. Here we review and discuss the impact of sex on human circadian and sleep physiology, and we uncover a data gap in the field investigating the non-visual effects of light in humans. A virtual workshop on the biomedical implications of sex differences in sleep and circadian physiology led to the following imperatives for future research: i) design research to be inclusive and accessible; ii) implement recruitment strategies that lead to a sex-balanced sample; iii) use data visualization to grasp the effect of sex; iv) implement statistical analyses that include sex as a factor and/or perform group analyses by sex, where possible; v) make participant-level data open and available to facilitate future meta-analytic efforts.
Identifiants
pubmed: 35179486
doi: 10.7554/eLife.65419
pii: 65419
pmc: PMC8963875
doi:
pii:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 204686/Z/16/A
Pays : United Kingdom
Informations de copyright
© 2022, Spitschan et al.
Déclaration de conflit d'intérêts
MS, NS, DF, NK, FL, IP, PV, RW No competing interests declared, AA Editor-in-Chief for the British Journal of Pharmacology, LH employee of the Wellcome Trust. Her work is unrelated to the Wellcome Trust's Research Enrichment funding mechanisms that funded the workshop
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