Pregnancy and severely reduced renal mass: A stress model showing renal hyperfiltration.
Hypertension
Nephron endowment
Pregnancy
Renal hyperfiltration
Journal
Pregnancy hypertension
ISSN: 2210-7797
Titre abrégé: Pregnancy Hypertens
Pays: Netherlands
ID NLM: 101552483
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
received:
07
06
2020
revised:
01
02
2022
accepted:
08
02
2022
pubmed:
19
2
2022
medline:
28
5
2022
entrez:
18
2
2022
Statut:
ppublish
Résumé
Pregnancy may increase signs of renovascular stress. We compared pregnant sham operated (S) and 5/6 nephrectomy (NX) rats to examine the effect of pregnancy on reduced nephron number. Blood pressure (BP), heart rate (HR), body weight (BW), food/water intake, serum creatinine (Cr), urinalyses were assessed weekly, and end pregnancy renal histology examined. NX showed decreased BW, elevated BP and Cr, and proteinuria. Histology revealed increased glomerular volume, increased tubular diameter and interstitial inflammation and fibrosis. This pilot shows that a pregnant 5/6th nephrectomy rat is a reliable model in which to evaluate renovascular stress with reduced nephrons.
Identifiants
pubmed: 35180659
pii: S2210-7789(22)00025-3
doi: 10.1016/j.preghy.2022.02.004
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
41-43Informations de copyright
Copyright © 2022 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.