Enuresis and Hyperfiltration in Children With Sickle Cell Disease.
Journal
Journal of pediatric hematology/oncology
ISSN: 1536-3678
Titre abrégé: J Pediatr Hematol Oncol
Pays: United States
ID NLM: 9505928
Informations de publication
Date de publication:
01 10 2022
01 10 2022
Historique:
received:
11
07
2021
accepted:
06
01
2022
pubmed:
19
2
2022
medline:
1
10
2022
entrez:
18
2
2022
Statut:
ppublish
Résumé
Nocturnal enuresis is a common symptom in children with sickle cell disease (SCD). Risk factors for development of enuresis are currently unknown. An early manifestation of SCD-associated kidney damage is glomerular hyperfiltration. We test the hypothesis that in a pediatric SCD cohort, individuals with hyperfiltration are more likely to have nocturnal enuresis when compared to children without hyperfiltration. To assess the relationship between nocturnal enuresis and hyperfiltration, we retrospectively evaluated children with SCD enrolled in the Evaluation of Nocturnal Enuresis and Barriers to Treatment among Pediatric Patients with SCD study and prospectively identified children who reported nocturnal enuresis and were enrolled in the longitudinal cohort study Sickle Cell Clinical Research and Intervention Program. Nocturnal enuresis occurred in 46.5% of Pediatric Patients with Sickle Cell Disease participants and was more frequent in participants with HbSS/HbSβ 0 thalassemia and in male participants. We did not identify an association between hyperfiltration from 3 to 5 years of age with the later development of enuresis. Severe SCD genotypes and male sex were associated with nocturnal enuresis after age 5 years. We could not identify additional renal or hematologic predictors associated with the diagnosis of nocturnal enuresis. Future studies should incorporate nonrenal risk factors into studies that predict development of enuresis.
Identifiants
pubmed: 35180759
doi: 10.1097/MPH.0000000000002426
pii: 00043426-202210000-00003
pmc: PMC9385885
mid: NIHMS1771178
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
358-362Subventions
Organisme : NHLBI NIH HHS
ID : K01 HL125495
Pays : United States
Organisme : NHLBI NIH HHS
ID : OT3 HL152448
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL133996
Pays : United States
Informations de copyright
Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
J.D.L. receives research support from NIH and is a consultant for Novartis on work that is not relevant to this work. J.S.H. receives research support from Global Blood Therapeutics and consultancy fees from Global Blood therapeutics, bluebird bio, Vindico medical education, and UpToDate and received funding from U01HL133996-05, 1OT3HL152448, and NU58DD000019 during conduct of this work. J.S.P. receives research support from K01HL125495. The remaining authors declare no conflict of interest.
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