Actions of Klotho on hippocampal neuronal cells.

Autophagy Glucuronidase / physiology Hippocampus / metabolism Klotho Proteins Neurons / metabolism
Autophagy Cell death DNA damage ER stress Hippocampus Inflammation Klotho Neurons Oxidative stress

Journal

Vitamins and hormones
ISSN: 0083-6729
Titre abrégé: Vitam Horm
Pays: United States
ID NLM: 0413601

Informations de publication

Date de publication:
2022
Historique:
entrez: 19 2 2022
pubmed: 20 2 2022
medline: 12 3 2022
Statut: ppublish

Résumé

Klotho gene was originally recognized as a putative aging-suppressor and its prominent age-regulating effects are mostly attributed to the modulation of mineral homeostasis in the kidney. However, recent studies link alterations in hippocampal Klotho expression with cognitive impairment and neurodegenerative diseases. This suggests that hippocampal neurons require Klotho for health and proper functionality. Klotho protects against neuronal dysfunction and regulates several intracellular signaling pathways including oxidative stress response, inflammation, DNA damage, autophagy, endoplasmic reticulum stress response, and multiple types of cell death. Specifically, this chapter covers the current knowledge as to how Klotho protein affects the hippocampal neuronal cells, with special attention paid to underlying molecular mechanisms, and thus influences hippocampal development, hippocampal-dependent cognition, behavior, and motor skills as well as mediates neurodegenerative processes.

Identifiants

DOI: 10.1016/bs.vh.2021.12.001 PMID: 35180928
pubmed: 35180928
pii: S0083-6729(21)00078-9
doi: 10.1016/bs.vh.2021.12.001
pii:
doi:

Substances chimiques

Glucuronidase EC 3.2.1.31
Klotho Proteins EC 3.2.1.31

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

223-246

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

Jennifer Mytych (J)

Department of Biotechnology, Institute of Biology and Biotechnology, Collegium Scientarium Naturalium, University of Rzeszow, Werynia, Poland. Electronic address: jennifermytych@gmail.com.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Autophagie › Actions of Klotho on hippocampal neuronal cells.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Glucuronidase › Actions of Klotho on hippocampal neuronal cells.
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Actions of Klotho on hippocampal neuronal cells.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteur facteur croissance fibroblaste › Protéines Klotho › Actions of Klotho on hippocampal neuronal cells.
questionsmedicales.fr › Cellules › Neurones › Actions of Klotho on hippocampal neuronal cells.