Folic Acid Supplementation in Early Pregnancy, Homocysteine Concentration, and Risk of Gestational Diabetes Mellitus.

Diabetes, Gestational / epidemiology Dietary Supplements Female Folic Acid / therapeutic use Homocysteine Humans Pregnancy Prospective Studies
folic acid gestational diabetes mellitus homocysteine methylenetetrahydrofolate reductase

Journal

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC
ISSN: 1701-2163
Titre abrégé: J Obstet Gynaecol Can
Pays: Netherlands
ID NLM: 101126664

Informations de publication

Date de publication:
Feb 2022
Historique:
received: 17 12 2020
revised: 04 06 2021
accepted: 04 06 2021
entrez: 19 2 2022
pubmed: 20 2 2022
medline: 25 3 2022
Statut: ppublish

Résumé

We used a prospective cohort of pregnant women at 12 to 20 weeks gestation between 2002 and 2008 in Ottawa and Kingston to evaluate the impact of early pregnancy folic acid supplementation on the risk of gestational diabetes mellitus. Among 7552 eligible women, 84 (1.11%) were diagnosed of gestational diabetes mellitus. Non-significant associations were observed between gestational diabetes mellitus and folate supplementation, homocysteine levels, and methylenetetrahydrofolate reductase 677 TT genotype. Although we found no significant associations between folic acid supplementation and the risk of gestational diabetes mellitus, genetic associations were not confounded by lifestyle or socioeconomic factors, which may have biased previous studies.

Identifiants

DOI: 10.1016/j.jogc.2021.06.005 PMID: 35181010
pubmed: 35181010
pii: S1701-2163(21)00496-5
doi: 10.1016/j.jogc.2021.06.005
pii:
doi:

Substances chimiques

Homocysteine 0LVT1QZ0BA
Folic Acid 935E97BOY8

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

196-199

Informations de copyright

Copyright © 2021 The Society of Obstetricians and Gynaecologists of Canada/La Société des obstétriciens et gynécologues du Canada. Published by Elsevier Inc. All rights reserved.

Auteurs

Yanfang Guo (Y)

Better Outcomes Registry & Network Ontario, Ottawa, ON; Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON; Department of Obstetrics, Gynecology, and Newborn Care, OMNI Research Group, University of Ottawa Faculty of Medicine, Ottawa, ON; School of Epidemiology and Public Health, University of Ottawa Faculty of Medicine, Ottawa, ON.

Rong Luo (R)

Department of Obstetrics, Gynecology, and Newborn Care, OMNI Research Group, University of Ottawa Faculty of Medicine, Ottawa, ON; School of Epidemiology and Public Health, University of Ottawa Faculty of Medicine, Ottawa, ON; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON.

Daniel J Corsi (DJ)

Better Outcomes Registry & Network Ontario, Ottawa, ON; Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON; Department of Obstetrics, Gynecology, and Newborn Care, OMNI Research Group, University of Ottawa Faculty of Medicine, Ottawa, ON; School of Epidemiology and Public Health, University of Ottawa Faculty of Medicine, Ottawa, ON; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON.

Ruth Rennicks White (RR)

Department of Obstetrics, Gynecology, and Newborn Care, OMNI Research Group, University of Ottawa Faculty of Medicine, Ottawa, ON; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON.

Graeme Smith (G)

Department of Obstetrics and Gynecology, Queen's Perinatal Research Unit, Kingston General Hospital, Queen's University, Kingston, ON.

Marc Rodger (M)

Department of Medicine, Division of Hematology, University of Ottawa, Ottawa, ON.

Ravi Retnakaran (R)

Division of Endocrinology and Metabolism, University of Toronto, Toronto, ON; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON.

Mark Walker (M)

Better Outcomes Registry & Network Ontario, Ottawa, ON; Department of Obstetrics, Gynecology, and Newborn Care, OMNI Research Group, University of Ottawa Faculty of Medicine, Ottawa, ON; School of Epidemiology and Public Health, University of Ottawa Faculty of Medicine, Ottawa, ON; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON.

Shi Wu Wen (SW)

Department of Obstetrics, Gynecology, and Newborn Care, OMNI Research Group, University of Ottawa Faculty of Medicine, Ottawa, ON; School of Epidemiology and Public Health, University of Ottawa Faculty of Medicine, Ottawa, ON; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON. Electronic address: swwen@ohri.ca.

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Classifications MeSH

questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète gestationnel › Folic Acid Supplementation in Early Pregnancy,...
questionsmedicales.fr › Aliments et boissons › Aliments › Compléments alimentaires › Folic Acid Supplementation in Early Pregnancy,...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Ptéridines › Acide folique › Folic Acid Supplementation in Early Pregnancy,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés soufrés › Homocystéine › Folic Acid Supplementation in Early Pregnancy,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Folic Acid Supplementation in Early Pregnancy,...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Folic Acid Supplementation in Early Pregnancy,...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Folic Acid Supplementation in Early Pregnancy,...