Optical imaging spectroscopy for rapid, primary screening of SARS-CoV-2: a proof of concept.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
18 02 2022
Historique:
received: 22 09 2021
accepted: 28 01 2022
entrez: 19 2 2022
pubmed: 20 2 2022
medline: 26 2 2022
Statut: epublish

Résumé

Effective testing is essential to control the coronavirus disease 2019 (COVID-19) transmission. Here we report a-proof-of-concept study on hyperspectral image analysis in the visible and near-infrared range for primary screening at the point-of-care of SARS-CoV-2. We apply spectral feature descriptors, partial least square-discriminant analysis, and artificial intelligence to extract information from optical diffuse reflectance measurements from 5 µL fluid samples at pixel, droplet, and patient levels. We discern preparations of engineered lentiviral particles pseudotyped with the spike protein of the SARS-CoV-2 from those with the G protein of the vesicular stomatitis virus in saline solution and artificial saliva. We report a quantitative analysis of 72 samples of nasopharyngeal exudate in a range of SARS-CoV-2 viral loads, and a descriptive study of another 32 fresh human saliva samples. Sensitivity for classification of exudates was 100% with peak specificity of 87.5% for discernment from PCR-negative but symptomatic cases. Proposed technology is reagent-free, fast, and scalable, and could substantially reduce the number of molecular tests currently required for COVID-19 mass screening strategies even in resource-limited settings.

Identifiants

pubmed: 35181702
doi: 10.1038/s41598-022-06393-3
pii: 10.1038/s41598-022-06393-3
pmc: PMC8857323
doi:

Types de publication

Evaluation Study Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2356

Subventions

Organisme : Instituto de Salud Carlos III
ID : COV20-00080
Organisme : Instituto de Salud Carlos III
ID : COV20-00173
Organisme : Ministerio de Ciencia e Innovación
ID : EQC2019-006240-P
Organisme : Agencia Estatal de Investigación
ID : RTI2018-094465-J

Informations de copyright

© 2022. The Author(s).

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Auteurs

Emilio Gomez-Gonzalez (E)

Department of Applied Physics III, ETSI School of Engineering, Universidad de Sevilla, Camino de los Descubrimientos s/n, 41092, Sevilla, Spain. egomez@us.es.
Institute of Biomedicine of Seville (IBIS), 41013, Sevilla, Spain. egomez@us.es.

Alejandro Barriga-Rivera (A)

Department of Applied Physics III, ETSI School of Engineering, Universidad de Sevilla, Camino de los Descubrimientos s/n, 41092, Sevilla, Spain.
School of Biomedical Engineering, The University of Sydney, Sydney, NSW, 2006, Australia.

Beatriz Fernandez-Muñoz (B)

Unidad de Producción y Reprogramación Celular (UPRC), Red Andaluza de Diseño y Traslación de Terapias Avanzadas, Consejería de Salud y Familias, Junta de Andalucía, 41092, Sevilla, Spain.

Jose Manuel Navas-Garcia (JM)

EOD-CBRN Group, Spanish National Police, 41011, Sevilla, Spain.

Isabel Fernandez-Lizaranzu (I)

Department of Applied Physics III, ETSI School of Engineering, Universidad de Sevilla, Camino de los Descubrimientos s/n, 41092, Sevilla, Spain.
Institute of Biomedicine of Seville (IBIS), 41013, Sevilla, Spain.

Francisco Javier Munoz-Gonzalez (FJ)

Department of Applied Physics III, ETSI School of Engineering, Universidad de Sevilla, Camino de los Descubrimientos s/n, 41092, Sevilla, Spain.

Ruben Parrilla-Giraldez (R)

Technology and Innovation Centre, Universidad de Sevilla, 41012, Sevilla, Spain.

Desiree Requena-Lancharro (D)

Department of Applied Physics III, ETSI School of Engineering, Universidad de Sevilla, Camino de los Descubrimientos s/n, 41092, Sevilla, Spain.

Pedro Gil-Gamboa (P)

Department of Applied Physics III, ETSI School of Engineering, Universidad de Sevilla, Camino de los Descubrimientos s/n, 41092, Sevilla, Spain.

Cristina Rosell-Valle (C)

Institute of Biomedicine of Seville (IBIS), 41013, Sevilla, Spain.
Unidad de Producción y Reprogramación Celular (UPRC), Red Andaluza de Diseño y Traslación de Terapias Avanzadas, Consejería de Salud y Familias, Junta de Andalucía, 41092, Sevilla, Spain.

Carmen Gomez-Gonzalez (C)

Service of Intensive Care, University Hospital 'Virgen del Rocio', 41013, Sevilla, Spain.
Department of Medicine, College of Medicine, Universidad de Sevilla, 41009, Seville, Spain.

Maria Jose Mayorga-Buiza (MJ)

Institute of Biomedicine of Seville (IBIS), 41013, Sevilla, Spain.
Service of Anesthesiology, University Hospital 'Virgen del Rocio', 41013, Sevilla, Spain.
Department of Surgery, College of Medicine, Universidad de Sevilla, 41009, Seville, Spain.

Maria Martin-Lopez (M)

Institute of Biomedicine of Seville (IBIS), 41013, Sevilla, Spain.
Unidad de Producción y Reprogramación Celular (UPRC), Red Andaluza de Diseño y Traslación de Terapias Avanzadas, Consejería de Salud y Familias, Junta de Andalucía, 41092, Sevilla, Spain.

Olga Muñoz (O)

Instituto de Astrofísica de Andalucía, CSIC, 18008, Granada, Spain.

Juan Carlos Gomez-Martin (JC)

Instituto de Astrofísica de Andalucía, CSIC, 18008, Granada, Spain.

Maria Isabel Relimpio-Lopez (MI)

Department of Surgery, College of Medicine, Universidad de Sevilla, 41009, Seville, Spain.
Department of Ophthalmology, University Hospital 'Virgen Macarena', 41009, Sevilla, Spain.
OftaRed, Institute of Health 'Carlos III', 28029, Madrid, Spain.

Jesus Aceituno-Castro (J)

Instituto de Astrofísica de Andalucía, CSIC, 18008, Granada, Spain.
Centro Astronomico Hispano Alemán, 04550, Almeria, Spain.

Manuel A Perales-Esteve (MA)

Department of Electronic Engineering, ETSI School of Engineering, Universidad de Sevilla, 41092, Sevilla, Spain.

Antonio Puppo-Moreno (A)

Service of Intensive Care, University Hospital 'Virgen del Rocio', 41013, Sevilla, Spain.
Department of Medicine, College of Medicine, Universidad de Sevilla, 41009, Seville, Spain.

Francisco Jose Garcia-Cozar (FJ)

Department of Biomedicine, Biotechnology and Public Health, University of Cadiz, 11003, Cadiz, Spain.

Lucia Olvera-Collantes (L)

Instituto de Investigación e Innovación Biomedica de Cádiz (INIBICA), 11009, Cadiz, Spain.

Raquel Gomez-Diaz (R)

Institute of Biomedicine of Seville (IBIS), 41013, Sevilla, Spain.

Silvia de Los Santos-Trigo (S)

Corporación Tecnológica de Andalucía, 41092, Sevilla, Spain.

Monserrat Huguet-Carrasco (M)

CER 'Dr. Gregorio Medina Blanco', 41807, Espartinas, Sevilla, Spain.

Manuel Rey (M)

CAMBRICO BIOTECH, 41015, Sevilla, Spain.

Emilia Gomez (E)

Joint Research Centre, European Commission, 41092, Sevilla, Spain.

Rosario Sanchez-Pernaute (R)

Unidad de Producción y Reprogramación Celular (UPRC), Red Andaluza de Diseño y Traslación de Terapias Avanzadas, Consejería de Salud y Familias, Junta de Andalucía, 41092, Sevilla, Spain.

Javier Padillo-Ruiz (J)

Institute of Biomedicine of Seville (IBIS), 41013, Sevilla, Spain.
Department of Surgery, College of Medicine, Universidad de Sevilla, 41009, Seville, Spain.
Department of General Surgery, University Hospital 'Virgen del Rocío', 41013, Sevilla, Spain.

Javier Marquez-Rivas (J)

Institute of Biomedicine of Seville (IBIS), 41013, Sevilla, Spain.
Department of Surgery, College of Medicine, Universidad de Sevilla, 41009, Seville, Spain.
Service of Neurosurgery, University Hospital 'Virgen del Rocío', 41013, Sevilla, Spain.
Centre for Advanced Neurology, 41013, Sevilla, Spain.

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Classifications MeSH