Discovery of actinomycin L, a new member of the actinomycin family of antibiotics.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
18 02 2022
Historique:
received: 21 11 2021
accepted: 01 02 2022
entrez: 19 2 2022
pubmed: 20 2 2022
medline: 12 3 2022
Statut: epublish

Résumé

Streptomycetes are major producers of bioactive natural products, including the majority of the naturally produced antibiotics. While much of the low-hanging fruit has been discovered, it is predicted that less than 5% of the chemical space of natural products has been mined. Here, we describe the discovery of the novel actinomycins L

Identifiants

pubmed: 35181725
doi: 10.1038/s41598-022-06736-0
pii: 10.1038/s41598-022-06736-0
pmc: PMC8857259
doi:

Substances chimiques

Anti-Bacterial Agents 0
Biological Products 0
actinomycin X2 0
ortho-Aminobenzoates 0
Dactinomycin 1CC1JFE158
anthranilamide Q1M2WEK6VA

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2813

Informations de copyright

© 2022. The Author(s).

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Auteurs

Nataliia V Machushynets (NV)

Molecular Biotechnology, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.

Somayah S Elsayed (SS)

Molecular Biotechnology, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.

Chao Du (C)

Molecular Biotechnology, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.

Maxime A Siegler (MA)

Department of Chemistry, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD, 21218, USA.

Mercedes de la Cruz (M)

Fundación MEDINA, Health Sciences Technology Park, Avda Conocimiento 34, 18016, Granada, Spain.

Olga Genilloud (O)

Fundación MEDINA, Health Sciences Technology Park, Avda Conocimiento 34, 18016, Granada, Spain.

Thomas Hankemeier (T)

Leiden Academic Centre for Drug Research (LACDR), Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.

Gilles P van Wezel (GP)

Molecular Biotechnology, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands. g.wezel@biology.leidenuniv.nl.

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Classifications MeSH