Chronic urticaria and thyroid autoimmunity: a meta-analysis of case-control studies.
Anti-thyroperoxidase antibodies
Autoimmune thyroiditis
Systematic review
Urticaria
Journal
Journal of endocrinological investigation
ISSN: 1720-8386
Titre abrégé: J Endocrinol Invest
Pays: Italy
ID NLM: 7806594
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
received:
03
01
2022
accepted:
07
02
2022
pubmed:
20
2
2022
medline:
14
6
2022
entrez:
19
2
2022
Statut:
ppublish
Résumé
Autoimmunity has been implicated in some patients with idiopathic chronic urticaria (CU). Because of the frequency of autoimmune thyroid diseases, their association with CU deserves special attention. We tested both the existence and the extent of an association between thyroid autoimmunity and CU. A thorough search of PubMed, Scopus, Web of Science, and Cochrane databases was performed. Studies reporting the positivity rate for anti-thyroperoxidase antibodies (TPOAbs) in people with (cases) and without CU (controls) were included. Quality of the studies was assessed by the Newcastle-Ottawa Scale. Between-study heterogeneity was assessed by Cochrane Q and I Nineteen studies provided information about TPOAbs positivity on 14,351 patients with CU and 12,404 controls. The pooled estimate indicated a more than fivefold increased risk of exhibiting TPOAbs positivity in the group with CU (pooled OR 5.18, 95% CI 3.27, 8.22; P < 0.00001). Correction for publication bias had a negligible effect on the overall estimate (pooled adjusted OR: 4.42, 95% CI 2.84, 6.87, P < 0.0001). Between‑study heterogeneity was established (I Patients with CU have a five-to-nearly sevenfold higher risk of displaying TPOAbs positivity. All patients with CU may well be offered a screening for thyroid autoimmunity.
Identifiants
pubmed: 35181847
doi: 10.1007/s40618-022-01761-2
pii: 10.1007/s40618-022-01761-2
pmc: PMC9184403
doi:
Types de publication
Journal Article
Meta-Analysis
Langues
eng
Sous-ensembles de citation
IM
Pagination
1317-1326Informations de copyright
© 2022. The Author(s).
Références
Powell RJ, Du Toit GL, Siddique N, Leech SC, Dixon TA, Clark AT, Mirakian R, Walker SM, Huber PA, Nasser SM, British Society for Allergy and Clinical Immunology (BSACI) (2007) BSACI guidelines for the management of chronic urticaria and angio-oedema. Clin Exp Allergy 37:631–650
pubmed: 17456211
Grattan CE (2007) Towards rationalizing the nomenclature and classification of urticaria: some guidance on guidelines. Clin Exp Allergy 37:625–626
pubmed: 17456209
Kulthanan K, Jiamton S, Thumpimukvatana N, Pinkaew S (2007) Chronic idiopathic urticaria: prevalence and clinical course. J Dermatol 34:294–301
pubmed: 17408437
Rottem M (2003) Chronic urticaria and autoimmune thyroid disease: is there a link? Autoimmun Rev 2:69–72
pubmed: 12848961
Dreskin SC, Andrews KY (2005) The thyroid and urticaria. Curr Opin Allergy Clin Immunol 5:408–412
pubmed: 16131915
Leznoff A, Josse RG, Denburg J, Dolovich J (1983) Association of chronic urticaria and angioedema with thyroid autoimmunity. Arch Dermatol 119:636–640
pubmed: 6870316
Gaig P, García-Ortega P, Enrique E, Richart C (2000) Successful treatment of chronic idiopathic urticaria associated with thyroid autoimmunity. J Investig Allergol Clin Immunol 10:342–345
pubmed: 11206934
Ryhal B, DeMera RS, Shoenfeld Y, Peter JB, Gershwin ME (2001) Are autoantibodies present in patients with subacute and chronic urticaria? J Investig Allergol Clin Immunol 11:16–20
pubmed: 11436965
Gangemi S, Saitta S, Lombardo G, Patafi M, Benvenga S (2009) Serum thyroid autoantibodies in patients with idiopathic either acute or chronic urticaria. J Endocrinol Invest 32:107–110
pubmed: 19411805
Fusari A, Colangelo C, Bonifazi F, Antonicelli L (2005) The autologous serum skin test in the follow-up of patients with chronic urticaria. Allergy 60:256–258
pubmed: 15647050
Palma-Carlos AG, Palma-Carlos ML (2005) Chronic urticaria and thyroid autoimmunity. Eur Ann Allergy Clin Immunol 37:143–146
pubmed: 15916015
Confino-Cohen R, Chodick G, Shalev V, Leshno M, Kimhi O, Goldberg A (2012) Chronic urticaria and autoimmunity: associations found in a large population study. J Allergy Clin Immunol 129:1307–1313
pubmed: 22336078
Díaz-Angulo S, López-Hoyos M, Muñoz Cacho P, Fernández M, López-Escobar M, Rodríguez F, González-López MA (2016) Prevalence of thyroid autoimmunity in spanish patients with chronic idiopathic urticaria: a case-control study involving 343 subjects. J Eur Acad Dermatol Venereol 30:692–693
pubmed: 25627749
Aamir IS, Tauheed S, Majeed F, Atif A (2008) Serum antithyroid antibodies in female patients with chronic urticaria. J Coll Physicians Surg Pak 18:498–501
pubmed: 18798586
Cebeci F, Tanrikut A, Topcu E, Onsun N, Kurtulmus N, Uras AR (2006) Association between chronic urticaria and thyroid autoimmunity. Eur J Dermatol 16:402–405
pubmed: 16935798
Czarnecka-Operacz M, Sadowska-Przytocka A, Jenerowicz D, Szeliga A, Adamski Z, Łącka K (2017) Thyroid function and thyroid autoantibodies in patients with chronic spontaneous urticaria. Postepy Dermatol Alergol 34:566–572
pubmed: 29422822
pmcid: 5799761
Kasumagic-Halilovic E, Beslic N, Ovcina-Kurtovic N (2017) Thyroid autoimmunity in patients with chronic urticaria. Med Arch 71:29–31
pubmed: 28428670
pmcid: 5364782
Magen E, Zueva E, Mishal J, Schlesinger M (2016) The clinical and laboratory characteristics of acute spontaneous urticaria and its progression to chronic spontaneous urticaria. Allergy Asthma Proc 37:394–399
pubmed: 27657523
Nuzzo V, Tauchmanova L, Colasanti P, Zuccoli A, Colao A (2011) Idiopathic chronic urticaria and thyroid autoimmunity: experience of a single center. Dermatoendocrinol 3:255–258
pubmed: 22259654
pmcid: 3256343
Al-Balbeesi AO (2011) Significance of antithyroid antibodies and other auto-antibodies in Saudi patients with chronic urticaria. Possible parameters in predicting chronic over three years disease. J Saudi Soc Dermatol Dermatologic Surg 15:47–51
Alpay A, Solak Tekin N, Tekin IÖ, Altinyazar HC, Koca R, Cınar S (2013) Autologous serum skin test versus autologous plasma skin test in patients with chronic spontaneous urticaria. Dermatol Res Pract. https://doi.org/10.1155/2013/267278
doi: 10.1155/2013/267278
pubmed: 23935607
pmcid: 3722846
Ghaffari J, Khademloo M, Mohammadzadeh I, Golpoor M (2013) Chronic urticaria: the necessity of laboratory examination. Zahedan J Res Med Sci 15:66–68
Okba AM, Sheha DS, Moustafa AS, El-Sherbeny AA, Mohamed NA, Aglan MF (2015) Association between thyroid autoimmunity and chronic urticaria in patients versus healthy controls. Egypt J Obes Diabetes Endocrinol 1:84–89
Turktas I, Gokcora N, Demirsoy S, Cakir N, Onal E (1997) The association of chronic urticaria and angioedema with autoimmune thyroiditis. Int J Dermatol 36:187–190
pubmed: 9158998
Verneuil L, Leconte C, Ballet JJ, Coffin C, Laroche D, Izard JP, Reznik Y, Leroy D (2004) Association between chronic urticaria and thyroid autoimmunity: a prospective study involving 99 patients. Dermatology 208:98–103
pubmed: 15056996
Wan KS, Wu CS (2013) The essential role of anti-thyroid antibodies in chronic idiopathic urticaria. Endocr Res 38:85–88
pubmed: 22889002
Yadav S, Kanwar A, Parsad D, Minz R (2013) Chronic idiopathic urticaria and thyroid autoimmunity: perplexing association. Indian J Dermatol 58:325
pubmed: 23919014
pmcid: 3726891
Cho CB, Stutes SA, Altrich ML, Ardoin SP, Phillips G, Ogbogu PU (2013) Autoantibodies in chronic idiopathic urticaria and nonurticarial systemic autoimmune disorders. Ann Allergy Asthma Immunol 110:29–33
pubmed: 23244655
pmcid: 3901433
Ferrari SM, Fallahi P, Santaguida G, Virili C, Ruffilli I, Ragusa F, Centanni M, Antonelli A (2017) Circulating CXCL10 is increased in non-segmental vitiligo, in presence or absence of autoimmune thyroiditis. Autoimmun Rev 16:946–950
pubmed: 28698095
Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA, PRISMA-P Group (2015) Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ 350:g7647
pubmed: 25555855
Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA, Thacker SB (2000) Meta analysis of observational studies in epidemiology: a proposal for reporting. JAMA 283:2008–2012
pubmed: 10789670
Deeks JJ, Dinnes J, D’Amico R, Sowden AJ, Sakarovitch C, Song F, Petticrew M, Altman DG, International Stroke Trial Collaborative Group; European Carotid Surgery Trial Collaborative Group (2003) Evaluating non-randomised intervention studies. Health Technol Assess 7(27):1–173
Mantel N, Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22:719–748
pubmed: 13655060
Greenland S, Robins JM (1985) Confounding and misclassification. Am J Epidemiol 122:495–506
pubmed: 4025298
Sterne JA, Egger M (2001) Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. J Clin Epidemiol 54:1046–1055
pubmed: 11576817
Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629–634
pubmed: 9310563
pmcid: 2127453
Duval S, Tweedie R (2000) Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 56:455–463
pubmed: 10877304
Barbonetti A, Martorella A, Minaldi E, D’Andrea S, Bardhi D, Castellini C, Francavilla F, Francavilla S (2019) Testicular cancer in infertile men with and without testicular microlithiasis: a systematic review and meta-analysis of case-control studies. Front Endocrinol (Lausanne) 10:164
Di Lorenzo G, Leto-Barone MS, La Piana S, Seidita A, Rini GB (2013) Chronic spontaneous urticaria: an autoimmune disease? A revision of the literature. Clin Exp Med 13:159–164
pubmed: 22584681
Berghi NO (2017) Immunological mechanisms implicated in the pathogenesis of chronic urticaria and hashimoto thyroiditis. Iran J Allergy Asthma Immunol 16:358–366
pubmed: 28865416
Gonzalez-Diaz SN, Sanchez-Borges M, Rangel-Gonzalez DM, Guzman-Avilan RI, Canseco-Villarreal JI, Arias-Cruz A (2020) Chronic urticaria and thyroid pathology. World Allergy Organ J 13:100101
pubmed: 32180891
pmcid: 7063156
Aversano M, Caiazzo P, Iorio G, Ponticiello L, Laganá B, Leccese F (2005) Improvement of chronic idiopathic urticaria with L-thyroxine: a new TSH role in immune response? Allergy 60:489–493
pubmed: 15727581
Koh CK, Hew FL, Chiu CL (2000) Treatment of chronic urticaria with thyroxine in an euthyroid patient with thyroglobulin and microsomal antibodies. Ann Acad Med Singap 29:528–530
pubmed: 11056786
Kiyici S, Gul OO, Baskan EB, Hacioglu S, Budak F, Erturk E, Imamoglu S (2010) Effect of levothyroxine treatment on clinical symptoms and serum cytokine levels in euthyroid patients with chronic idiopathic urticaria and thyroid autoimmunity. Clin Exp Dermatol 35:603–607
pubmed: 19874329
Magen E, Mishal J (2012) The effect of L-thyroxine treatment on chronic idiopathic urticaria and autoimmune thyroiditis. Int J Dermatol 51:94–97
pubmed: 22182385
Eckman JA, Hamilton RG, Gober LM, Sterba PM, Saini SS (2008) Basophil phenotypes in chronic idiopathic urticaria in relation to disease activity and autoantibodies. J Invest Dermatol 128:1956–1963
pubmed: 18356810
Tanaka T, Kishimoto T (2014) The biology and medical implications of interleukin-6. Cancer Immunol Res 2:288–294
pubmed: 24764575
Kasperska-Zajac A, Sztylc J, Machura E (2011) Plasma IL-6 concentration correlates with clinical disease activity and serum C-reactive protein concentration in chronic urticaria patients. Clin Exp Allergy 41:1386–1391
pubmed: 21645137
Bai X, Sun J, Wang W, Shan Z, Zheng H, Li Y, Zhao Y, Gong M, Teng W (2014) Increased differentiation of Th22 cells in Hashimoto’s thyroiditis. Endocr J 61:1181–1190
pubmed: 25242258
Al-Jameil N, Khan MF, Al-Rashid M, Tabassum H (2015) Thyroid dysfunction: an autoimmune aspect. Int J Clin Exp Med 8(5):6677
pubmed: 26221205
pmcid: 4509150
Valencia X, Lipsky PE (2007) CD4+ CD25+ FoxP3+ regulatory T cells in autoimmune diseases. Nat Clin Pract Rheumatol 3(11):619–626
pubmed: 17968332
Arshi S, Babaie D, Nabavi M, Tebianian M, Ghalehbaghi B, Jalali F, Ahmadvand A, Gholami R (2014) Circulating level of CD4+ CD25+ FOXP3+ T cells in patients with chronic urticaria. Int J Dermatol 53:e561–e566
pubmed: 25311400
Sun RS, Sui JF, Chen XH, Ran XZ, Yang ZF, Guan WD, Yang T (2011) Detection of CD4+ CD25+ FOXP3+ regulatory T cells in peripheral blood of patients with chronic autoimmune urticaria. Australas J Dermatol 52:e15–e18
pubmed: 21834806
Chen WC, Chiang BL, Liu HE, Leu SJ, Lee YL (2008) Defective functions of circulating CD4+CD25+ and CD4+CD25- T cells in patients with chronic ordinary urticaria. J Dermatol Sci 51:121–130
pubmed: 18440785
Glick AB, Wodzinski A, Fu P, Levine AD, Wald DN (2013) Impairment of regulatory T-cell function in autoimmune thyroid disease. Thyroid 23:871–878
pubmed: 23379353
pmcid: 3704106
Xue H, Yu X, Ma L, Song S, Li Y, Zhang L, Yang T, Liu H (2015) The possible role of CD4
pubmed: 25771887
Pan XF, Gu JQ, Shan ZY (2015) The prevalence of thyroid autoimmunity in patients with urticaria: a systematic review and meta-analysis. Endocrine 48:804–810
pubmed: 25064381
Rotondi M, Coperchini F, Magri F, Chiovato L (2014) Serum-negative autoimmune thyroiditis: what’s in a name? J Endocrinol Invest 37:589–591
pubmed: 24789542