A combined role for low vitamin D and low albumin circulating levels as strong predictors of worse outcome in COVID-19 patients.
COVID-19
Human serum albumin
SARS-CoV-2
Vitamin D
Journal
Irish journal of medical science
ISSN: 1863-4362
Titre abrégé: Ir J Med Sci
Pays: Ireland
ID NLM: 7806864
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
28
08
2021
accepted:
08
02
2022
pubmed:
20
2
2022
medline:
4
2
2023
entrez:
19
2
2022
Statut:
ppublish
Résumé
We aimed to assess the combined role of vitamin D and albumin serum levels as predictors of COVID-19 disease progression. We conducted a prospective observational study on adult patients hospitalized for SARS-CoV-2 pneumonia (March-September 2020). Vitamin D and albumin serum levels were measured on admission. These variables were categorized in albumin < 3.5 or ≥ 3.5 g/dL and vitamin D < 30 ng/mL or ≥ 30 ng/mL. We excluded patients with known bone diseases, renal failure, hypercalcemia and/or treated with antiepileptic drugs and steroids, and patients who received previous vitamin D supplementation. A composite outcome including any ventilatory support, PaO Sixty-nine patients were enrolled, of whom 50% received non-invasive (NIV) or invasive mechanical ventilation (IMV), 10% died, whereas 89% and 66% presented low albumin and low vitamin D serum levels, respectively. No correlation between vitamin D and albumin levels was found. In multivariable logistic regression analyses adjusted for sex and age-corrected comorbidities, patients having albumin < 3.5 g/dL and vitamin D < 30 ng/mL showed a significant increased risk for all study outcomes, namely NIV/IMV (OR 3.815; 95% CI 1.122-12.966; p = 0.032), NIV/IMV or death (OR 3.173; 95% CI 1.002-10.043; p = 0.049) and PaO The measurement of both vitamin D and serum albumin levels on COVID-19 patients' admission, and their combined evaluation, provides a simple prognostic tool that could be employed to guide prompt clinical decisions.
Identifiants
pubmed: 35182287
doi: 10.1007/s11845-022-02952-9
pii: 10.1007/s11845-022-02952-9
pmc: PMC8857533
doi:
Substances chimiques
Vitamin D
1406-16-2
Types de publication
Observational Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
423-430Informations de copyright
© 2022. The Author(s).
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