Bacterial infection disrupts established germinal center reactions through monocyte recruitment and impaired metabolic adaptation.

B cell LPS Listeria Salmonella bacterial infection germinal center inflammation monocytes

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
08 03 2022
Historique:
received: 02 06 2021
revised: 11 10 2021
accepted: 18 01 2022
pubmed: 20 2 2022
medline: 6 5 2022
entrez: 19 2 2022
Statut: ppublish

Résumé

Consecutive exposures to different pathogens are highly prevalent and often alter the host immune response. However, it remains unknown how a secondary bacterial infection affects an ongoing adaptive immune response elicited against primary invading pathogens. We demonstrated that recruitment of Sca-1

Identifiants

pubmed: 35182483
pii: S1074-7613(22)00042-5
doi: 10.1016/j.immuni.2022.01.013
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

442-458.e8

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Adi Biram (A)

Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: adi.biram@weizmann.ac.il.

Jingjing Liu (J)

Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.

Hadas Hezroni (H)

Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.

Natalia Davidzohn (N)

Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel; Department of Biological Regulation, Weizmann Institute of Science, Rehovot 7610001, Israel.

Dominik Schmiedel (D)

Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.

Eman Khatib-Massalha (E)

Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.

Montaser Haddad (M)

Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.

Amalie Grenov (A)

Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.

Sacha Lebon (S)

Department of Biological Regulation, Weizmann Institute of Science, Rehovot 7610001, Israel.

Tomer Meir Salame (TM)

Department of Life Science Core Facilities, Weizmann Institute of Science, Rehovot 7610001, Israel.

Nili Dezorella (N)

Electron Microscopy Unit, Weizmann Institute of Science, Rehovot 7610001, Israel.

Dotan Hoffman (D)

Department of Biological Regulation, Weizmann Institute of Science, Rehovot 7610001, Israel.

Paula Abou Karam (P)

Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel.

Moshe Biton (M)

Department of Biological Regulation, Weizmann Institute of Science, Rehovot 7610001, Israel.

Tsvee Lapidot (T)

Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.

Mats Bemark (M)

Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg SE-405 30, Sweden.

Roi Avraham (R)

Department of Biological Regulation, Weizmann Institute of Science, Rehovot 7610001, Israel.

Steffen Jung (S)

Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.

Ziv Shulman (Z)

Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: ziv.shulman@weizmann.ac.il.

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Classifications MeSH