GOLGI: Cancer cell fate control.
Calcium/Ca(2+)
Cancer
Cell death
Cell motility
Golgi
pH
Journal
The international journal of biochemistry & cell biology
ISSN: 1878-5875
Titre abrégé: Int J Biochem Cell Biol
Pays: Netherlands
ID NLM: 9508482
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
30
12
2021
revised:
11
02
2022
accepted:
12
02
2022
pubmed:
20
2
2022
medline:
6
5
2022
entrez:
19
2
2022
Statut:
ppublish
Résumé
Growing evidence connects many of the Golgi known functions with cellular events related to cancer initiation and progression, including regulation of cell survival/death, proliferation, motility, metabolism and immune evasion. However, a broad and integrated understanding of the impact of the Golgi on cancer cell phenotype has not yet been achieved. Multiple cellular events involving the Golgi are associated with protein and lipid modification and trafficking. However, less explored aspects of this enigmatic organelle also contribute to cell fate decision-making by impacting signal transduction, redox and ion homeostasis. This article focuses on the molecular mechanisms and Golgi proteins underlying the impact of the Golgi on cancer cell phenotype. Special emphasis is given to emerging knowledge on redox and ion homeostasis. Current and potential cancer progression therapeutic strategies associated with this organelle will also be addressed.
Identifiants
pubmed: 35182766
pii: S1357-2725(22)00019-X
doi: 10.1016/j.biocel.2022.106174
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
106174Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.