Regulatory mechanisms of the early phase of white adipocyte differentiation: an overview.
Adipogenesis
Cytoskeleton
Epigenome modifications
Obesity
Transcriptional control of differentiation
Journal
Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402
Informations de publication
Date de publication:
20 Feb 2022
20 Feb 2022
Historique:
received:
27
10
2021
accepted:
24
01
2022
revised:
10
01
2022
entrez:
20
2
2022
pubmed:
21
2
2022
medline:
1
3
2022
Statut:
epublish
Résumé
The adipose organ comprises two main fat depots termed white and brown adipose tissues. Adipogenesis is a process leading to newly differentiated adipocytes starting from precursor cells, which requires the contribution of many cellular activities at the genome, transcriptome, proteome, and metabolome levels. The adipogenic program is accomplished through two sequential phases; the first includes events favoring the commitment of adipose tissue stem cells/precursors to preadipocytes, while the second involves mechanisms that allow the achievement of full adipocyte differentiation. While there is a very large literature about the mechanisms involved in terminal adipogenesis, little is known about the first stage of this process. Growing interest in this field is due to the recent identification of adipose tissue precursors, which include a heterogenous cell population within different types of adipose tissue as well as within the same fat depot. In addition, the alteration of the heterogeneity of adipose tissue stem cells and of the mechanisms involved in their commitment have been linked to adipose tissue development defects and hence to the onset/progression of metabolic diseases, such as obesity. For this reason, the characterization of early adipogenic events is crucial to understand the etiology and the evolution of adipogenesis-related pathologies, and to explore the adipose tissue precursors' potential as future tools for precision medicine.
Identifiants
pubmed: 35184223
doi: 10.1007/s00018-022-04169-6
pii: 10.1007/s00018-022-04169-6
pmc: PMC8858922
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
139Subventions
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : Progetto eccellenza 2018-2022
Organisme : European Foundation for the Study of Diabetes
ID : MSD European Research Programme on New Targets for Type 2 Diabetes 2019
Organisme : Giovanni Armenise-Harvard Foundation
ID : Career development award
Informations de copyright
© 2022. The Author(s).
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