Social and Biological Parameters Involved in Suicide Ideation During the COVID-19 Pandemic: A Narrative Review.
Covid-19
inflammatory cytokines
neurobiological factors
psychiatric disorder
suicidal behavior
suicidal death
Journal
International journal of tryptophan research : IJTR
ISSN: 1178-6469
Titre abrégé: Int J Tryptophan Res
Pays: United States
ID NLM: 101513378
Informations de publication
Date de publication:
2020
2020
Historique:
received:
01
09
2020
accepted:
08
11
2020
entrez:
21
2
2022
pubmed:
21
12
2020
medline:
21
12
2020
Statut:
epublish
Résumé
Fear is an indispensable characteristic of any infectious disease, and the alarm will be further amplified when the infection spreads uncontrollable, unpredictable, and global. The novel corona virus (SARS CoV-2) lead Covid-19, has been declared as a global emergency by WHO as it has affected millions of people with a high mortality rate. The non-availability of medicine for Covid-19 and the various control measures such as social distancing, self-isolation, house quarantine, and the new normal implementation by different nations across the world to control the spread of Covid-19 made people vulnerable to fear and anxiety. As a result, considerable number of Covid-19-related suicidal deaths has been reported across the world during this pandemic. There have been several studies which describe the psychosocial aspects of suicidal ideation. However, the research on the biological aspects of suicidal ideation/suicidal risk factors that are related to pandemic are unreported. Hence this review article is intended to provide a comprehensive analysis of suicidal deaths during Covid-19 and also aimed to addresses the possible link between suicidal ideation and different factors, including psycho-social, behavioral, neurobiological factors (proximal, distal, and inflammatory) and immunity. The alterations in glutamatergic and GABAergic neurotransmitters had upregulated the GABARB3, GABARA4, GABARA3, GABARR1, GABARG2, and GAD2 gene expressions in suicidal victims. The changes in the Kynurenine (KYN) pathway, Hypothalamus-Pituitary-Adrenal axis (HPA axis) hyperactivation, and dysregulation of serotonin biosynthesis would significantly alter the brain chemistry in people with suicide ideation.
Identifiants
pubmed: 35185341
doi: 10.1177/1178646920978243
pii: 10.1177_1178646920978243
pmc: PMC8851148
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1178646920978243Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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