Regional Associations of Cortical Superficial Siderosis and β-Amyloid-Positron-Emission-Tomography Positivity in Patients With Cerebral Amyloid Angiopathy.

This is a cross-sectional study to evaluate whether β-amyloid-(Aβ)-PET positivity and cortical superficial siderosis (cSS) in patients with cerebral amyloid angiopathy (CAA) are regionally colocalized. Ten patients with probable or possible CAA (73.3 ± 10.9 years, 40% women) underwent MRI examination with a gradient-echo-T2*-weighted-imaging sequence to detect cSS and cSS- and Aβ-PET positivity did not indicate similarity of their regional patterns, despite a minor association between the frequency of Aβ-positive patients and the frequency of cSS-positive patients within individual regions ( In this cross-sectional study, cSS and Aβ-PET positivity did not show regional association in patients with CAA and deserve further exploitation in longitudinal designs. In clinical routine, a specific cross-sectional evaluation of Aβ-PET in cSS-positive regions is probably not useful for visual reading of Aβ-PETs in patients with CAA.

Informations de copyright

Copyright © 2022 Finze, Wahl, Janowitz, Buerger, Linn, Rominger, Stöcklein, Bartenstein, Wollenweber, Catak and Brendel.

Déclaration de conflit d'intérêts

MB received speaker honoraria from GE Healthcare, Roche and LMI and is an advisor of LMI. AR and PB received speaker honoraria from GE Healthcare. JL received speaker honoraria from Bayer Vital GmbH and is an advisory board member of Mediaire GmbH and Biogen GmbH. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.