Angiogenic Role of Mesothelium-Derived Chemokine CXCL1 During Unfavorable Peritoneal Tissue Remodeling in Patients Receiving Peritoneal Dialysis as Renal Replacement Therapy.
COVID-19
/ pathology
Cells, Cultured
Chemokine CXCL1
/ metabolism
Child
Child, Preschool
Epithelium
/ metabolism
Humans
Infant
Interleukin-17
/ metabolism
Kidney Failure, Chronic
/ therapy
Neovascularization, Pathologic
/ pathology
Peritoneal Dialysis
/ methods
Peritoneum
/ blood supply
Renal Replacement Therapy
/ methods
Vascular Endothelial Growth Factor A
/ metabolism
Vascular Remodeling
/ physiology
COVID-19
CXC chemokine ligand 1 (CXCL1)
angiogenesis
cytokine/chemokine-signaling
end-stage renal disease (ESRD)
interleukin 17
mesothelium
peritoneal dialysis (PD)
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
24
11
2021
accepted:
19
01
2022
entrez:
21
2
2022
pubmed:
22
2
2022
medline:
3
3
2022
Statut:
epublish
Résumé
Peritoneal dialysis (PD) is a valuable 'home treatment' option, even more so during the ongoing Coronavirus pandemic. However, the long-term use of PD is limited by unfavourable tissue remodelling in the peritoneal membrane, which is associated with inflammation-induced angiogenesis. This appears to be driven primarily through vascular endothelial growth factor (VEGF), while the involvement of other angiogenic signaling pathways is still poorly understood. Here, we have identified the crucial contribution of mesothelial cell-derived angiogenic CXC chemokine ligand 1 (CXCL1) to peritoneal angiogenesis in PD. CXCL1 expression and peritoneal microvessel density were analysed in biopsies obtained by the International Peritoneal Biobank (NCT01893710 at www.clinicaltrials.gov), comparing 13 children with end-stage kidney disease before initiating PD to 43 children on chronic PD. The angiogenic potential of mesothelial cell-derived CXCL1 was assessed
Identifiants
pubmed: 35185912
doi: 10.3389/fimmu.2022.821681
pmc: PMC8854359
doi:
Substances chimiques
CXCL1 protein, human
0
Chemokine CXCL1
0
IL17A protein, human
0
Interleukin-17
0
VEGFA protein, human
0
Vascular Endothelial Growth Factor A
0
Banques de données
ClinicalTrials.gov
['NCT01893710']
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
821681Informations de copyright
Copyright © 2022 Catar, Bartosova, Kawka, Chen, Marinovic, Zhang, Zhao, Wu, Zickler, Stadnik, Karczewski, Kamhieh-Milz, Jörres, Moll, Schmitt and Witowski.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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