Dissecting the mechanism of cytokine release induced by T-cell engagers highlights the contribution of neutrophils.
Cancer immunotherapy
PBMC
T cell bispecific antibodies
T cell engagers
cytokine release syndrome
neutrophil
Journal
Oncoimmunology
ISSN: 2162-402X
Titre abrégé: Oncoimmunology
Pays: United States
ID NLM: 101570526
Informations de publication
Date de publication:
2022
2022
Historique:
entrez:
21
2
2022
pubmed:
22
2
2022
medline:
9
4
2022
Statut:
epublish
Résumé
T cell engagers represent a novel promising class of cancer-immunotherapies redirecting T cells to tumor cells and have some promising outcomes in the clinic. These molecules can be associated with a mode-of-action related risk of cytokine release syndrome (CRS) in patients. CRS is characterized by the rapid release of pro-inflammatory cytokines such as TNF-α, IFN-γ, IL-6 and IL-1β and immune cell activation eliciting clinical symptoms of fever, hypoxia and hypotension. In this work, we investigated the biological mechanisms triggering and amplifying cytokine release after treatment with T cell bispecific antibodies (TCBs) employing an
Identifiants
pubmed: 35186442
doi: 10.1080/2162402X.2022.2039432
pii: 2039432
pmc: PMC8855852
doi:
Substances chimiques
Antibodies, Bispecific
0
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2039432Informations de copyright
© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.
Déclaration de conflit d'intérêts
All authors, except A. Odermatt, are employees of Roche or were employed by Roche at the time of this study and declare patent. All the authors, except A. Odermatt, G. Leclercq, N. Steinhoff, declare ownership of Roche stock.
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