The Histone H3K27me3 Demethylases KDM6A/B Resist Anoikis and Transcriptionally Regulate Stemness-Related Genes.
CD44
HIF1α
SOX2
anoikis
histone demethylases
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2022
2022
Historique:
received:
20
09
2021
accepted:
10
01
2022
entrez:
21
2
2022
pubmed:
22
2
2022
medline:
22
2
2022
Statut:
epublish
Résumé
Epithelial cancer cells that lose attachment from the extracellular matrix (ECM) to seed in a distant organ often undergo anoikis's specialized form of apoptosis. Recently, KDM3A (H3K9 demethylase) has been identified as a critical effector of anoikis in cancer cells. However, whether other histone demethylases are involved in promoting or resisting anoikis remains elusive. We screened the major histone demethylases and found that both H3K27 histone demethylases, namely, KDM6A/B were highly expressed during ECM detachment. Inhibition of the KDM6A/B activity by using a specific inhibitor results in reduced sphere formation capacity and increased apoptosis. Knockout of KDM6B leads to the loss of stem cell properties in solitary cells. Furthermore, we found that KDM6B maintains stemness by transcriptionally regulating the expression of stemness genes
Identifiants
pubmed: 35186918
doi: 10.3389/fcell.2022.780176
pii: 780176
pmc: PMC8847600
doi:
Types de publication
Journal Article
Langues
eng
Pagination
780176Informations de copyright
Copyright © 2022 Shait Mohammed, Zamzami, Choudhry, Ahmed, Ateeq and Khan.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Int J Cell Biol. 2012;2012:306879
pubmed: 22505926
J Clin Invest. 2019 Aug 8;129(11):4745-4757
pubmed: 31393857
Cell Stem Cell. 2010 Aug 6;7(2):150-61
pubmed: 20682444
Int J Mol Sci. 2021 May 22;22(11):
pubmed: 34067305
Cancer Lett. 2008 Dec 18;272(2):177-85
pubmed: 18579285
Front Cell Infect Microbiol. 2020 May 06;10:205
pubmed: 32435625
Mol Cell. 2014 Aug 21;55(4):537-51
pubmed: 25042802
Cancer Res. 2016 Nov 15;76(22):6520-6532
pubmed: 27651311
Clin Transl Med. 2015 Feb 26;4:6
pubmed: 25852822
Stem Cells. 2010 Dec;28(12):2141-50
pubmed: 20945330
Cell. 2014 Aug 28;158(5):1110-1122
pubmed: 25171411
Biochim Biophys Acta. 2013 Dec;1833(12):3481-3498
pubmed: 23830918
J Biol Chem. 2012 Dec 28;287(53):44508-17
pubmed: 23152497
Nat Rev Cancer. 2014 Sep;14(9):632-41
pubmed: 25098270
Elife. 2016 Jul 29;5:
pubmed: 27472901
Sci Rep. 2021 Feb 2;11(1):2784
pubmed: 33531586
Nucleic Acids Res. 2018 Jul 27;46(13):6576-6591
pubmed: 29860315
Cell. 2006 May 5;125(3):483-95
pubmed: 16603237
Nature. 2016 Dec 8;540(7632):236-241
pubmed: 27798602
Cell Signal. 2018 Nov;51:243-256
pubmed: 30121333
Nature. 2014 Oct 2;514(7520):E1-2
pubmed: 25279926
J Clin Invest. 2019 Aug 12;129(9):3852-3863
pubmed: 31403472
Leukemia. 2019 Oct;33(10):2506-2521
pubmed: 30936419
Oncotarget. 2017 Jul 11;8(28):46691-46703
pubmed: 28493839
Development. 2016 Oct 15;143(20):3674-3685
pubmed: 27802135
BMC Cancer. 2010 Jun 17;10:297
pubmed: 20565761
Cell. 2019 Jan 10;176(1-2):98-112.e14
pubmed: 30633912
Int J Biochem Cell Biol. 2015 Oct;67:148-57
pubmed: 26193001
Nat Commun. 2014 Dec 22;5:5780
pubmed: 25531312
Front Oncol. 2021 Feb 25;11:612778
pubmed: 33718166
Nat Rev Cancer. 2009 Apr;9(4):265-73
pubmed: 19262571
Science. 2011 Mar 25;331(6024):1559-64
pubmed: 21436443
BMC Cancer. 2010 Sep 29;10:517
pubmed: 20920234