ADP-Ribosylation Factor Family of Small GTP-Binding Proteins: Their Membrane Recruitment, Activation, Crosstalk and Functions.

Arf GAP Arf GEF Arf proteins cargo adaptor cargo sorting vesicular trafficking

Journal

Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250

Informations de publication

Date de publication:
2022
Historique:
received: 11 11 2021
accepted: 14 01 2022
entrez: 21 2 2022
pubmed: 22 2 2022
medline: 22 2 2022
Statut: epublish

Résumé

Members of the ADP-ribosylation factor (ARF) family of guanine-nucleotide binding proteins play critical roles in various cellular processes, especially in regulating the secretory, and endocytic pathways. The fidelity of intracellular vesicular trafficking depends on proper activations and precise subcellular distributions of ARF family proteins regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Here we review recent progress in understanding the membrane recruitment, activation, crosstalk, and functions of ARF family proteins.

Identifiants

pubmed: 35186926
doi: 10.3389/fcell.2022.813353
pii: 813353
pmc: PMC8850633
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

813353

Informations de copyright

Copyright © 2022 Li and Guo.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Tiantian Li (T)

Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Kowloon, Hong Kong SAR, China.

Yusong Guo (Y)

Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Kowloon, Hong Kong SAR, China.
Hong Kong University of Science and Technology, Shenzhen Research Institute, Shenzhen, China.
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, China.

Classifications MeSH