High-Throughput Screen for Inhibitors of
Journal
ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658
Informations de publication
Date de publication:
15 Feb 2022
15 Feb 2022
Historique:
received:
23
11
2021
accepted:
08
12
2021
entrez:
21
2
2022
pubmed:
22
2
2022
medline:
22
2
2022
Statut:
epublish
Résumé
The continuing emergence of antibacterial resistance reduces the effectiveness of antibiotics and drives an ongoing search for effective replacements. Screening compound libraries for antibacterial activity in standard growth media has been extensively explored and may be showing diminishing returns. Inhibition of bacterial targets that are selectively important under in vivo (infection) conditions and, therefore, would be missed by conventional in vitro screens might be an alternative. Surrogate host models of infection, however, are often not suitable for high-throughput screens. Here, we adapted a medium-throughput
Identifiants
pubmed: 35187355
doi: 10.1021/acsomega.1c06633
pmc: PMC8851646
doi:
Types de publication
Journal Article
Langues
eng
Pagination
5401-5414Informations de copyright
© 2022 The Authors. Published by American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare the following competing financial interest(s): All authors were employed at Novartis at the time of their contributions to this work and would have received compensation in the form of salary and may have received Novartis stock.
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