A global picture: therapeutic perspectives for COVID-19.
COVID-19
SARS-CoV-2
coronavirus
drug discovery process
drug repurposing
drug target
pandemic
vaccines
Journal
Immunotherapy
ISSN: 1750-7448
Titre abrégé: Immunotherapy
Pays: England
ID NLM: 101485158
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
pubmed:
22
2
2022
medline:
16
3
2022
entrez:
21
2
2022
Statut:
ppublish
Résumé
The COVID-19 pandemic is a lethal virus outbreak by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which has severely affected human lives and the global economy. The most vital part of the research and development of therapeutic agents is to design drug products to manage COVID-19 efficiently. Numerous attempts have been in place to determine the optimal drug dose and combination of drugs to treat the disease on a global scale. This article documents the information available on SARS-CoV-2 and its life cycle, which will aid in the development of the potential treatment options. A consolidated summary of several natural and repurposed drugs to manage COVID-19 is depicted with summary of current vaccine development. People with high age, comorbity and concomitant illnesses such as overweight, metabolic disorders, pulmonary disease, coronary heart disease, renal failure, fatty liver and neoplastic disorders are more prone to create serious COVID-19 and its consequences. This article also presents an overview of post-COVID-19 complications in patients. Severe acute respiratory syndrome coronavirus-2 causes the coronavirus disease i.e., COVID-19. This article encompasses basic information about coronavirus and COVID-19. It includes information about viral transmission and subsequent events for COVID-19 in a person, and it presents different drugs and vaccines utilized for the management of COVID-19. Several natural drugs are proposed to manage COVID-19. It also has an overview about post-COVID-19 complications in recovered patients.
Autres résumés
Type: plain-language-summary
(eng)
Severe acute respiratory syndrome coronavirus-2 causes the coronavirus disease i.e., COVID-19. This article encompasses basic information about coronavirus and COVID-19. It includes information about viral transmission and subsequent events for COVID-19 in a person, and it presents different drugs and vaccines utilized for the management of COVID-19. Several natural drugs are proposed to manage COVID-19. It also has an overview about post-COVID-19 complications in recovered patients.
Identifiants
pubmed: 35187954
doi: 10.2217/imt-2021-0168
pmc: PMC8884157
doi:
Substances chimiques
Antiviral Agents
0
COVID-19 Vaccines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
351-371Commentaires et corrections
Type : CommentIn
Type : CommentIn
Références
N Engl J Med. 2020 Mar 26;382(13):1199-1207
pubmed: 31995857
iScience. 2020 Jul 24;23(7):101303
pubmed: 32622261
N Engl J Med. 2021 Aug 12;385(7):585-594
pubmed: 34289274
J Environ Public Health. 2021 Apr 22;2021:6631721
pubmed: 33953756
Lancet Gastroenterol Hepatol. 2020 May;5(5):428-430
pubmed: 32145190
Nature. 2021 Dec;600(7887):21
pubmed: 34824381
Ann Intern Med. 2020 Oct 20;173(8):670-672
pubmed: 32422065
Antimicrob Agents Chemother. 2014 Aug;58(8):4885-93
pubmed: 24841273
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
Bioinformatics. 2019 Oct 1;35(19):3672-3678
pubmed: 30840053
N Engl J Med. 2021 Feb 25;384(8):693-704
pubmed: 32678530
J Transl Autoimmun. 2021;4:100083
pubmed: 33521616
FEBS J. 2014 Sep;281(18):4085-96
pubmed: 25039866
Int J Biol Sci. 2020 Mar 15;16(10):1708-1717
pubmed: 32226288
Int J Antimicrob Agents. 2020 Aug;56(2):105998
pubmed: 32360231
Int J Infect Dis. 2021 Feb;103:25-32
pubmed: 33186704
J Biomol Struct Dyn. 2021 Sep;39(15):5735-5755
pubmed: 32679006
Transl Psychiatry. 2020 May 12;10(1):141
pubmed: 32398742
J Biosci. 2020;45:
pubmed: 32661214
Front Immunol. 2020 Jul 10;11:1712
pubmed: 32754164
Commun Biol. 2021 Feb 12;4(1):197
pubmed: 33580154
Front Immunol. 2021 Apr 12;12:669339
pubmed: 33912196
Eur J Med Chem Rep. 2021 Dec;3:100013
pubmed: 36575695
Curr Med Chem. 2019;26(28):5389-5409
pubmed: 29848268
MAbs. 2020 Jan-Dec;12(1):1854149
pubmed: 33319649
Front Mol Biosci. 2021 Aug 30;8:725528
pubmed: 34527703
Int J Antimicrob Agents. 2020 Sep;56(3):106114
pubmed: 32712334
Hum Vaccin Immunother. 2021 Jul 3;17(7):1897-1909
pubmed: 33577374
Nature. 2020 Jul;583(7815):290-295
pubmed: 32422645
Lancet Diabetes Endocrinol. 2017 Nov;5(11):898-907
pubmed: 28689769
Curr Pharm Des. 2006;12(11):1315-38
pubmed: 16611118
Mycoses. 2021 Aug;64(8):798-808
pubmed: 33590551
Biologics. 2020 Aug 25;14:77-82
pubmed: 32921981
Nat Rev Microbiol. 2021 Jul;19(7):409-424
pubmed: 34075212
Expert Rev Anti Infect Ther. 2021 Feb;19(2):147-163
pubmed: 32853038
J Tradit Complement Med. 2011 Oct;1(1):41-50
pubmed: 24716104
Nat Commun. 2020 May 4;11(1):2251
pubmed: 32366817
J Pharm Anal. 2020 Aug;10(4):320-328
pubmed: 32346490
Eur J Pharmacol. 2021 Mar 5;894:173836
pubmed: 33387467
AAPS J. 2021 Jan 5;23(1):14
pubmed: 33400058
Biomed Pharmacother. 2021 Jun;138:111518
pubmed: 33774315
Drug Discov Today. 2021 Nov;26(11):2619-2636
pubmed: 34332100
Inform Med Unlocked. 2020;20:100407
pubmed: 32835083
Front Microbiol. 2020 Jul 23;11:1796
pubmed: 32793181
Acta Pharmacol Sin. 2020 Sep;41(9):1141-1149
pubmed: 32747721
Drug Discov Today. 2019 Jun;24(6):1232-1236
pubmed: 30935985
Nutrients. 2020 Jan 16;12(1):
pubmed: 31963293
Lancet Glob Health. 2021 May;9(5):e590-e592
pubmed: 33667404
JAMA. 2021 Jul 6;326(1):35-45
pubmed: 34037666
Nat Med. 2020 Apr;26(4):450-452
pubmed: 32284615
Nat Rev Microbiol. 2021 Mar;19(3):155-170
pubmed: 33116300
Med J Armed Forces India. 2020 Oct;76(4):370-376
pubmed: 32895599
Signal Transduct Target Ther. 2020 Oct 6;5(1):223
pubmed: 33024071
Annu Rev Virol. 2016 Sep 29;3(1):237-261
pubmed: 27578435
Virusdisease. 2020 Mar;31(1):28-37
pubmed: 32206696
Nature. 2021 May;593(7860):491
pubmed: 34012131
Med Res Rev. 2021 May;41(3):1775-1797
pubmed: 33393116
Nat Rev Genet. 2021 Dec;22(12):757-773
pubmed: 34535792
Evid Based Complement Alternat Med. 2021 Feb 27;2021:8814890
pubmed: 33727943
mSystems. 2021 May 4;6(3):
pubmed: 33947804
Adv Sci (Weinh). 2021 Sep;8(17):e2101222
pubmed: 34180141
Curr Opin Pharmacol. 2020 Apr;51:78-92
pubmed: 31982325
NPJ Vaccines. 2021 Feb 22;6(1):28
pubmed: 33619260
Inflamm Regen. 2020 Oct 5;40:24
pubmed: 33024459
Intensive Care Med. 2020 Apr;46(4):586-590
pubmed: 32125455
J Microbiol Immunol Infect. 2021 Apr;54(2):159-163
pubmed: 32265180
Nat Rev Drug Discov. 2019 Jan;18(1):41-58
pubmed: 30310233
Nat Rev Drug Discov. 2020 Sep;19(9):578
pubmed: 32719377
N Engl J Med. 2020 Jun 11;382(24):2372-2374
pubmed: 32302078
Viruses. 2020 Jan 24;12(2):
pubmed: 31991541
J Am Coll Nutr. 2013;32(5):321-30
pubmed: 24219375
Lancet Infect Dis. 2020 Jun;20(6):669-677
pubmed: 32240634
J Intern Med. 2021 Feb;289(2):147-161
pubmed: 32696489
PLoS One. 2021 Sep 28;16(9):e0257784
pubmed: 34582497
Front Immunol. 2020 Aug 26;11:2037
pubmed: 32983152
Front Pharmacol. 2021 May 28;12:671498
pubmed: 34122096
Eur J Pharmacol. 2020 Sep 15;883:173372
pubmed: 32682787
Signal Transduct Target Ther. 2021 Mar 8;6(1):114
pubmed: 33686059
Biol Pharm Bull. 2008 Nov;31(11):2063-7
pubmed: 18981574
N Engl J Med. 2021 Sep 23;385(13):1172-1183
pubmed: 34192426
Bioorg Med Chem. 2010 Nov 15;18(22):7940-7
pubmed: 20934345
N Engl J Med. 2021 May 13;384(19):1866-1868
pubmed: 33761203
Theranostics. 2021 Jan 1;11(4):1690-1702
pubmed: 33408775
ACS Med Chem Lett. 2020 Aug 10;11(9):1663-1666
pubmed: 32934769
Trends Immunol. 2021 Jan;42(1):31-44
pubmed: 33281063
Nature. 2020 Aug;584(7819):115-119
pubmed: 32454513
EClinicalMedicine. 2021 Oct;40:101102
pubmed: 34485873
Cell Discov. 2020 Mar 16;6:14
pubmed: 32194980
Science. 2020 Aug 21;369(6506):956-963
pubmed: 32540903
Inflammopharmacology. 2021 Aug;29(4):1001-1016
pubmed: 34110533
Theranostics. 2020 Jun 19;10(17):7821-7835
pubmed: 32685022
Future Virol. 2019 Apr;14(4):275-286
pubmed: 32201500
Cleve Clin J Med. 2020 Jun 8;:
pubmed: 32513807
iScience. 2020 Oct 09;23(11):101656
pubmed: 33134890
Curr Biol. 2020 Apr 6;30(7):1346-1351.e2
pubmed: 32197085
Front Cell Infect Microbiol. 2020 Nov 25;10:587269
pubmed: 33324574
Parasitology. 2020 May;147(6):611-633
pubmed: 32046803
Cleve Clin J Med. 2020 Nov 23;87(12):715
pubmed: 33229384
J Biomol Struct Dyn. 2021 Jun;39(9):3396-3408
pubmed: 32367767
Semin Immunopathol. 2017 Jul;39(5):529-539
pubmed: 28466096
Nature. 2021 May;593(7858):178-179
pubmed: 33948031
PLoS Pathog. 2020 May 14;16(5):e1008421
pubmed: 32407364
Indian J Med Microbiol. 2021 Oct-Dec;39(4):417-422
pubmed: 34454775
Lancet Respir Med. 2020 Aug;8(8):822-830
pubmed: 32559419
Lancet Infect Dis. 2020 Apr;20(4):400-402
pubmed: 32113509
JAMA. 2021 Jun 22;325(24):2448-2456
pubmed: 33929487
Biosaf Health. 2021 Apr;3(2):87-91
pubmed: 33585808
BMJ. 2021 Dec 3;375:n3011
pubmed: 34862175
Postgrad Med J. 2021 Jun;97(1148):391-398
pubmed: 33008960
Diabetes Metab Syndr. 2021 Jul-Aug;15(4):102146
pubmed: 34192610
N Engl J Med. 2021 Jan 21;384(3):238-251
pubmed: 33332778
Clin Exp Immunol. 2020 Nov;202(2):162-192
pubmed: 32935331
Vaccines (Basel). 2021 Jun 10;9(6):
pubmed: 34200587
Aging (Albany NY). 2020 Aug 15;12(15):15784-15796
pubmed: 32805728
Crit Rev Clin Lab Sci. 2020 Sep;57(6):365-388
pubmed: 32645276
J Enzyme Inhib Med Chem. 2020 Dec;35(1):145-151
pubmed: 31724441
Expert Opin Drug Discov. 2020 Apr;15(4):397-401
pubmed: 31847616
Compr Rev Food Sci Food Saf. 2004 Oct;3(4):127-139
pubmed: 33430565
Virol J. 2020 Sep 24;17(1):141
pubmed: 32972430
J Virol. 2010 Apr;84(7):3595-602
pubmed: 20071563
Nat Commun. 2020 May 20;11(1):2601
pubmed: 32433465
Pharmacol Rep. 2020 Dec;72(6):1479-1508
pubmed: 32889701
Eur Radiol. 2020 Jun;30(6):3266-3267
pubmed: 32072255
Turk J Med Sci. 2020 Apr 15;50(SI-1):611-619
pubmed: 32293834
Diabetes Metab Syndr. 2020 Jul - Aug;14(4):407-412
pubmed: 32335367
Med Hypotheses. 2020 Jul;140:109782
pubmed: 32353743
Hum Vaccin Immunother. 2020 Jun 2;16(6):1239-1242
pubmed: 32298218
Expert Rev Vaccines. 2021 Dec;20(12):1549-1560
pubmed: 34582298
Nature. 2021 May;593(7859):325-326
pubmed: 33963317
Postgrad Med J. 2021 May;97(1147):312-320
pubmed: 32978337
Interdiscip Sci. 2015 Sep;7(3):257-65
pubmed: 26223545
Lancet Infect Dis. 2021 Feb;21(2):181-192
pubmed: 33217362
Lancet. 2021 Oct 9;398(10308):1377-1380
pubmed: 34534516
Methods Mol Biol. 2019;1953:89-103
pubmed: 30912017
J Biomol Struct Dyn. 2021 May;39(8):3025-3033
pubmed: 32274964
Chem Biol Interact. 2018 May 25;288:49-56
pubmed: 29653099
Int J Antimicrob Agents. 2020 Jun;55(6):105982
pubmed: 32305588
Nat Commun. 2020 Mar 27;11(1):1620
pubmed: 32221306
J Emerg Nurs. 2000 Feb;26(1):51-5
pubmed: 10657800
JAMA. 2020 May 12;323(18):1824-1836
pubmed: 32282022
J Med Virol. 2020 Nov;92(11):2368-2370
pubmed: 32472703
Clin Infect Dis. 2022 Aug 24;75(1):e822-e826
pubmed: 34915551
Med Drug Discov. 2021 Jun;10:100090
pubmed: 33817623
J Crit Care. 2020 Jun;57:279-283
pubmed: 32173110
Immunity. 2020 Jul 14;53(1):98-105.e5
pubmed: 32561270
J Med Chem. 2016 Apr 28;59(8):3635-49
pubmed: 27014922
Front Med (Lausanne). 2021 Jan 18;7:559811
pubmed: 33537320
Maturitas. 2021 Dec;154:58-61
pubmed: 34364730
Signal Transduct Target Ther. 2020 Oct 13;5(1):237
pubmed: 33051445
Biomolecules. 2019 Nov 04;9(11):
pubmed: 31690059
Int J Infect Dis. 2021 Jan;102:501-508
pubmed: 33130203
Nutrients. 2020 Apr 02;12(4):
pubmed: 32252338
JAMA Intern Med. 2021 Sep 1;181(9):1241-1243
pubmed: 34028504
Nat Rev Immunol. 2020 Aug;20(8):507-514
pubmed: 32576980
Int J Mol Sci. 2021 Feb 16;22(4):
pubmed: 33669456
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Eur J Pharmacol. 2021 Mar 15;895:173890
pubmed: 33482181
Cell. 2020 Nov 12;183(4):1013-1023.e13
pubmed: 32970990
N Engl J Med. 2020 May 21;382(21):2012-2022
pubmed: 32227758
Emerg Microbes Infect. 2021 Dec;10(1):1790-1806
pubmed: 34427172
Virus Res. 2020 Dec;290:198169
pubmed: 32979476
Int J Mol Sci. 2019 Dec 29;21(1):
pubmed: 31905745
Mayo Clin Proc. 2020 Nov;95(11):2382-2394
pubmed: 33153629
Front Plant Sci. 2020 Nov 27;11:589995
pubmed: 33329653
JAMA. 2021 Feb 9;325(6):529-531
pubmed: 33404586
Cureus. 2020 Mar 26;12(3):e7423
pubmed: 32337143
Signal Transduct Target Ther. 2021 Jun 11;6(1):233
pubmed: 34117216
J Ethnopharmacol. 2008 Jun 19;118(1):79-85
pubmed: 18479853
Pharmacol Ther. 2021 Dec;228:107930
pubmed: 34174275
J Med Virol. 2021 Jan;93(1):275-299
pubmed: 32617987
Sci Rep. 2020 Dec 11;10(1):21775
pubmed: 33311551
Clin Immunol. 2020 May;214:108393
pubmed: 32222466
Nature. 2021 May;593(7857):130-135
pubmed: 33684923
Hong Kong Med J. 2011 Feb;17 Suppl 2:41-3
pubmed: 21368336
Braz J Infect Dis. 2020 Jul - Aug;24(4):369-371
pubmed: 32615072
N Engl J Med. 2021 Apr 22;384(16):1503-1516
pubmed: 33631066
ACS Cent Sci. 2021 Apr 28;7(4):512-533
pubmed: 34056083
Cell Mol Immunol. 2020 Jul;17(7):765-767
pubmed: 32047258
IEEE J Biomed Health Inform. 2019 May;23(3):1304-1315
pubmed: 30010603
Signal Transduct Target Ther. 2021 Mar 6;6(1):112
pubmed: 33677470
F1000Res. 2020 Aug 17;9:
pubmed: 32850116
Virology. 2020 Dec;551:1-9
pubmed: 33010669
Antiviral Res. 2005 Oct;68(1):36-42
pubmed: 16115693