Modelled lung deposition and retention of welding fume particles in occupational scenarios: a comparison to doses used in vitro.
Exposure
In vitro
Lung dose
Particle deposition
Welding
Journal
Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
16
12
2021
accepted:
02
02
2022
pubmed:
22
2
2022
medline:
12
4
2022
entrez:
21
2
2022
Statut:
ppublish
Résumé
Translating particle dose from in vitro systems to relevant human exposure remains a major challenge for the use of in vitro studies in assessing occupational hazard and risk of particle exposure. This study aimed to model the lung deposition and retention of welding fume particles following occupational scenarios and subsequently compare the lung doses to those used in vitro. We reviewed published welding fume concentrations and size distributions to identify input values simulating real-life exposure scenarios in the multiple path particle dosimetry (MPPD) model. The majority of the particles were reported to be below 0.1 μm and mass concentrations ranged between 0.05 and 45 mg/m
Identifiants
pubmed: 35188583
doi: 10.1007/s00204-022-03247-9
pii: 10.1007/s00204-022-03247-9
pmc: PMC8921161
doi:
Substances chimiques
Air Pollutants, Occupational
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
969-985Subventions
Organisme : Svenska Forskningsrådet Formas
ID : 2017-00883
Organisme : VINNOVA
ID : 2018-03336
Informations de copyright
© 2022. The Author(s).
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