Nucleosides and emerging viruses: A new story.
(Re)emerging RNA viruses
Antiviral therapy
Broad-spectrum antiviral agents
Nucleoside analogues
RNA-dependent RNA polymerase (RdRp)
Journal
Drug discovery today
ISSN: 1878-5832
Titre abrégé: Drug Discov Today
Pays: England
ID NLM: 9604391
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
07
10
2021
revised:
13
01
2022
accepted:
16
02
2022
pubmed:
22
2
2022
medline:
22
6
2022
entrez:
21
2
2022
Statut:
ppublish
Résumé
With several US Food and Drug Administration (FDA)-approved drugs and high barriers to resistance, nucleoside and nucleotide analogs remain the cornerstone of antiviral therapies for not only herpesviruses, but also HIV and hepatitis viruses (B and C); however, with the exception of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), for which vaccines have been developed at unprecedented speed, there are no vaccines or small antivirals yet available for (re)emerging viruses, which are primarily RNA viruses. Thus, herein, we present an overview of ribonucleoside analogs recently developed and acting as inhibitors of the viral RNA-dependent RNA polymerase (RdRp). They are new lead structures that will be exploited for the discovery of new antiviral nucleosides.
Identifiants
pubmed: 35189369
pii: S1359-6446(22)00070-8
doi: 10.1016/j.drudis.2022.02.013
pmc: PMC8856764
pii:
doi:
Substances chimiques
Antiviral Agents
0
Nucleosides
0
RNA-Dependent RNA Polymerase
EC 2.7.7.48
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1945-1953Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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