Bilateral Leydig Cell Hyperplasia: A Rare Cause of Postmenopausal Hirsutism.
Journal
Case reports in endocrinology
ISSN: 2090-6501
Titre abrégé: Case Rep Endocrinol
Pays: United States
ID NLM: 101576457
Informations de publication
Date de publication:
2022
2022
Historique:
received:
28
10
2021
accepted:
27
01
2022
entrez:
22
2
2022
pubmed:
23
2
2022
medline:
23
2
2022
Statut:
epublish
Résumé
Postmenopausal hirsutism could be due to a myriad of causes, including ovarian and adrenal tumours, ovarian hyperthecosis, exogenous androgens, and Cushing's syndrome. We report a patient who was found to have a rare cause of postmenopausal hirsutism. Evaluation of postmenopausal hirsutism needs careful history and examination followed by biochemical evaluation and imaging. While adrenal and ovarian venous sampling can help to arrive at a diagnosis, it is a technically demanding procedure with low success rates even at centers of excellence. Therefore, in such situations, bilateral oophorectomy may be the best course of action which will give the histological confirmation of the diagnosis. Successful treatment of hyperandrogenism can result in improvement of glycaemic control. Bilateral diffuse Leydig cell hyperplasia is a rare but important cause of postmenopausal hirsutism.
Sections du résumé
BACKGROUND
BACKGROUND
Postmenopausal hirsutism could be due to a myriad of causes, including ovarian and adrenal tumours, ovarian hyperthecosis, exogenous androgens, and Cushing's syndrome. We report a patient who was found to have a rare cause of postmenopausal hirsutism.
CONCLUSION
CONCLUSIONS
Evaluation of postmenopausal hirsutism needs careful history and examination followed by biochemical evaluation and imaging. While adrenal and ovarian venous sampling can help to arrive at a diagnosis, it is a technically demanding procedure with low success rates even at centers of excellence. Therefore, in such situations, bilateral oophorectomy may be the best course of action which will give the histological confirmation of the diagnosis. Successful treatment of hyperandrogenism can result in improvement of glycaemic control. Bilateral diffuse Leydig cell hyperplasia is a rare but important cause of postmenopausal hirsutism.
Identifiants
pubmed: 35190778
doi: 10.1155/2022/8804856
pmc: PMC8858062
doi:
Types de publication
Case Reports
Langues
eng
Pagination
8804856Informations de copyright
Copyright © 2022 S. Pathmanathan et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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