Polygenic risk scores for neuropsychiatric, inflammatory, and cardio-metabolic traits highlight possible genetic overlap with suicide attempt and treatment-emergent suicidal ideation.
gene sets
major depressive disorder
polygenic risk scores
suicide
treatment-worsening/emergent suicidal ideation
Journal
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
ISSN: 1552-485X
Titre abrégé: Am J Med Genet B Neuropsychiatr Genet
Pays: United States
ID NLM: 101235742
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
revised:
01
10
2021
received:
09
03
2021
accepted:
31
01
2022
pubmed:
23
2
2022
medline:
1
6
2022
entrez:
22
2
2022
Statut:
ppublish
Résumé
Suicide is the second cause of death among youths. Genetics may contribute to suicidal phenotypes and their co-occurrence in other neuropsychiatric and medical conditions. Our study aimed to investigate the association of polygenic risk scores (PRSs) for 24 neuropsychiatric, inflammatory, and cardio-metabolic traits/diseases with suicide attempt (SA) or treatment-worsening/emergent suicidal ideation (TWESI). PRSs were computed based on summary statistics of genome-wide association studies. Regression analyses were performed between PRSs and SA or TWESI in four clinical cohorts. Results were then meta-analyzed across samples, including a total of 688 patients with SA (N
Identifiants
pubmed: 35191176
doi: 10.1002/ajmg.b.32891
pmc: PMC9305542
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
74-85Subventions
Organisme : NIMH NIH HHS
ID : NCT00021528
Pays : United States
Organisme : NIMH NIH HHS
ID : N01MH900001
Pays : United States
Organisme : NIMH NIH HHS
ID : N01MH8001
Pays : United States
Organisme : NIMH NIH HHS
ID : N01MH90003
Pays : United States
Informations de copyright
© 2022 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics published by Wiley Periodicals LLC.
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