Antibacterial composite hydrogels of graphene quantum dots and bacterial cellulose accelerate wound healing.
antibacterial activity
bacterial cellulose
dressings
graphene quantum dots
wound healing treatment
Journal
Journal of biomedical materials research. Part B, Applied biomaterials
ISSN: 1552-4981
Titre abrégé: J Biomed Mater Res B Appl Biomater
Pays: United States
ID NLM: 101234238
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
revised:
02
02
2022
received:
09
09
2021
accepted:
09
02
2022
pubmed:
23
2
2022
medline:
14
6
2022
entrez:
22
2
2022
Statut:
ppublish
Résumé
The increased antibiotic resistance of pathogenic bacteria requires intense research of new wound healing agents. Novel wound dressings should be designed to provide wound disinfection, good moisture, and fast epithelization. In this study, bacterial cellulose (BC) was impregnated with graphene quantum dots (GQDs) for potential use in wound healing treatment. The BC was successfully loaded with approximately 11.7 wt% of GQDs. The actual release of GQDs from new designed composite hydrogels were 13%. Novel GQDs-BC hydrogel composites are biocompatible and showed significant inhibition towards Staphylococcus aureus and Streptococcus agalactiae and bactericidal effect towards Methicillin-resistant Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. The in vitro healing analysis showed significant migration of human fibroblasts after the GQDs-BC hydrogels application. Furthermore, after 72 h exposure to GQDs-BC, endothelial nitric oxide synthase, vascular endothelial growth factor A, matrix metallopeptidase 9, and Vimentin gene expression in fibroblast were significantly upregulated promoting angiogenesis. GQDs-BC hydrogel composites showed very good wound fluid absorption and water retention, which satisfies good dressing properties. All obtained results propose new designed GQDs-BC hydrogels as potential wound dressings.
Substances chimiques
Anti-Bacterial Agents
0
Hydrogels
0
Vascular Endothelial Growth Factor A
0
Graphite
7782-42-5
Cellulose
9004-34-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1796-1805Subventions
Organisme : Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
ID : 451-03-2/2021-14/20-0302102
Organisme : Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
ID : TR31079
Informations de copyright
© 2022 Wiley Periodicals LLC.
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