Short latency afferent inhibition: comparison between threshold-tracking and conventional amplitude recording methods.
Amplitude measurement
Short latency afferent inhibition
Threshold-tracking
Variability
Journal
Experimental brain research
ISSN: 1432-1106
Titre abrégé: Exp Brain Res
Pays: Germany
ID NLM: 0043312
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
31
10
2021
accepted:
05
02
2022
pubmed:
23
2
2022
medline:
21
4
2022
entrez:
22
2
2022
Statut:
ppublish
Résumé
Short-latency afferent inhibition (SAI), which is conventionally measured as a reduction in motor evoked potential amplitude (A-SAI), is of clinical interest as a potential biomarker for cognitive impairment. Since threshold-tracking has some advantages for clinical studies of short-interval cortical inhibition, we have compared A-SAI with a threshold-tracking alternative method (T-SAI). In the T-SAI method, inhibition was calculated by tracking the required TMS intensity for the targeted MEP amplitude (200 uV) both for the test (TMS only) and paired (TMS and peripheral stimulation) stimuli. A-SAI and T-SAI were recorded from 31 healthy subjects using ten stimuli at each of 12 inter-stimulus intervals, once in the morning and again in the afternoon. There were no differences between morning and afternoon recordings. When A-SAI was normalized by log conversion it was closely related to T-SAI. Between subjects, variability was similar for the two techniques, but within-subject variability was significantly smaller for normalized A-SAI. Conventional amplitude measurements appear more sensitive for detecting changes within-subjects, such as in interventional studies, but threshold-tracking may be as sensitive as detecting abnormal SAI in a patient.
Identifiants
pubmed: 35192042
doi: 10.1007/s00221-022-06327-5
pii: 10.1007/s00221-022-06327-5
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1241-1247Subventions
Organisme : Medical Research Council
ID : MR/K015222/1
Pays : United Kingdom
Organisme : Lundbeckfonden
ID : R290-2018-751
Organisme : Lundbeckfonden
ID : R346-2020-1946
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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