Association between host genetics of sheep and the rumen microbial composition.
Candidate genes
Genome-wide association studies
Host genetics
Rumen microbiota
Sheep
Journal
Tropical animal health and production
ISSN: 1573-7438
Titre abrégé: Trop Anim Health Prod
Pays: United States
ID NLM: 1277355
Informations de publication
Date de publication:
22 Feb 2022
22 Feb 2022
Historique:
received:
30
01
2021
accepted:
04
01
2022
entrez:
22
2
2022
pubmed:
23
2
2022
medline:
25
2
2022
Statut:
epublish
Résumé
A synergy between the rumen microbiota and the host genetics has created a symbiotic relationship, beneficial to the host's health. In this study, the association between the host genetics and rumen microbiome of Damara and Meatmaster sheep was investigated. The composition of rumen microbiota was estimated through the analysis of the V3-V4 region of the 16S rRNA gene, while the sheep blood DNA was genotyped with Illumina OvineSNP50 BeadChip and the genome-wide association (GWA) was analyzed. Sixty significant SNPs dispersed in 21 regions across the Ovis aries genome were found to be associated with the relative abundance of seven genera: Acinetobacter, Bacillus, Clostridium, Flavobacterium, Prevotella, Pseudomonas, and Streptobacillus. A total of eighty-four candidate genes were identified, and their functional annotations were mainly associated with immunity responses and function, metabolism, and signal transduction. Our results propose that those candidate genes identified in the study may be modulating the composition of rumen microbiota and further indicating the significance of comprehending the interactions between the host and rumen microbiota to gain better insight into the health of sheep.
Identifiants
pubmed: 35192073
doi: 10.1007/s11250-022-03057-2
pii: 10.1007/s11250-022-03057-2
doi:
Substances chimiques
RNA, Ribosomal, 16S
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
109Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature B.V.
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pubmed: 28877472
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