Myocardial perfusion quantification with Rb-82 PET: good interobserver agreement of Carimas software on global, regional, and segmental levels.
Absolute quantification
Agreement
Carimas
Imaging software
Myocardial blood flow
Myocardial perfusion quantification
PET standardization
Quantitative imaging
Reproducibility
Rubidium-82
Standards in nuclear cardiology
Journal
Annals of nuclear medicine
ISSN: 1864-6433
Titre abrégé: Ann Nucl Med
Pays: Japan
ID NLM: 8913398
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
received:
14
10
2021
accepted:
09
02
2022
pubmed:
23
2
2022
medline:
28
5
2022
entrez:
22
2
2022
Statut:
ppublish
Résumé
To estimate the interobserver agreement of the Carimas software package (SP) on global, regional, and segmental levels for the most widely used myocardial perfusion PET tracer-Rb-82. Rest and stress Rb-82 PET scans of 48 patients with suspected or known coronary artery disease (CAD) were analyzed in four centers using the Carimas SP. We considered values to agree if they simultaneously had an intraclass correlation coefficient (ICC) > 0.75 and a difference < 20% of the median across all observers. The median values on the segmental level were 1.08 mL/min/g for rest myocardial blood flow (MBF), 2.24 mL/min/g for stress MBF, and 2.17 for myocardial flow reserve (MFR). For the rest MBF and MFR, all the values at all the levels fulfilled were in excellent agreement. For stress MBF, at the global and regional levels, all the 24 comparisons showed excellent agreement. Only 1 out of 102 segmental comparisons (seg. 14) was over the adequate agreement limit-23.5% of the median value (ICC = 0.95). Interobserver agreement for Rb-82 PET myocardial perfusion quantification analyzed with Carimas is good at any LV segmentation level-global, regional, and segmental. It is good for all the estimates-rest MBF, stress MBF, and MFR.
Identifiants
pubmed: 35192160
doi: 10.1007/s12149-022-01729-5
pii: 10.1007/s12149-022-01729-5
pmc: PMC9132838
doi:
Substances chimiques
Rubidium Radioisotopes
0
Rubidium-82
9K730EL8KU
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
507-514Informations de copyright
© 2022. The Author(s).
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