Frequency- and spike-timing-dependent mitochondrial Ca

Ca2+ signaling axon cortical pyramidal neuron dendrite mitochondria mouse neuroscience spike-timing-dependent plasticity

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
22 02 2022
Historique:
received: 11 10 2021
accepted: 20 02 2022
pubmed: 23 2 2022
medline: 30 4 2022
entrez: 22 2 2022
Statut: epublish

Résumé

Mitochondrial activity is crucial for the plasticity of central synapses, but how the firing pattern of pre- and postsynaptic neurons affects the mitochondria remains elusive. We recorded changes in the fluorescence of cytosolic and mitochondrial Ca

Identifiants

pubmed: 35192454
doi: 10.7554/eLife.74606
pii: 74606
pmc: PMC8906805
doi:
pii:

Banques de données

Dryad
['10.5061/dryad.sxksn0348']

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIA NIH HHS
ID : RF1 AG065628
Pays : United States

Informations de copyright

© 2022, Stoler et al.

Déclaration de conflit d'intérêts

OS, AS, YK, IM, GS, DG, IS, IF No competing interests declared

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Auteurs

Ohad Stoler (O)

Department of Physiology and Cell Biology, Faculty of Health Sciences and Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer Sheva, Israel.

Alexandra Stavsky (A)

Department of Physiology and Cell Biology, Faculty of Health Sciences and Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer Sheva, Israel.

Yana Khrapunsky (Y)

Department of Physiology and Cell Biology, Faculty of Health Sciences and Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer Sheva, Israel.

Israel Melamed (I)

Department of Neurosurgery, Faculty of Health Sciences and Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer Sheva, Israel.

Grace Stutzmann (G)

Rosalind Franklin University of Medicine and Science, Chicago Medical School, Center for Neurodegenerative Disease and Therapeutics, North Chicago, United States.

Daniel Gitler (D)

Department of Physiology and Cell Biology, Faculty of Health Sciences and Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer Sheva, Israel.

Israel Sekler (I)

Department of Physiology and Cell Biology, Faculty of Health Sciences and Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer Sheva, Israel.

Ilya Fleidervish (I)

Department of Physiology and Cell Biology, Faculty of Health Sciences and Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer Sheva, Israel.

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